历年文献基因敲除小鼠_转基因小鼠定制

                            
                            Fuzheng Huayu formula attenuates ductular reaction and liver fibrosis potentially through suppressing Gli1 pathway
                        

产品名称：Mdr2-KO

研究领域：扶正化瘀方;肝纤维化;胆管反应;Gli1通路;中药药理

发表年份：2026 发表杂志：JOURNAL OF ETHNOPHARMACOLOGY

                            
                            Identification of biomarkers associated with pathological dynamic progression in dystrophinopathies
                        

产品名称：Dmd-Q995X

研究领域：肌营养不良蛋白病;杜氏肌营养不良;蛋白质组学/代谢组学

发表年份：2026 发表杂志：Scientific Reports

                            
                            Bacteroides thetaiotaomicron Improves Colorectal Cancer Prognosis by Remodeling the Immune Microenvironment
                        

产品名称：B2m-KO

研究领域：结直肠癌;多形拟杆菌;肿瘤免疫微环境重塑;肠道菌群;微生物组-免疫互作

发表年份：2026 发表杂志：JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

                            
                            Therapeutic pressure drives the evolution of a protective ecotype characterized by AR-loss-induced senescence in prostate cancer
                        

产品名称：Pbsn-CreERT;Pten-KO;Trp53-KO;Col1a2-CreERT;Ar-KO

研究领域：前列腺癌;治疗诱导进化;雄激素受体缺失;细胞衰老;肿瘤生态型;表型可塑性

发表年份：2026 发表杂志：Theranostics

                            
                            IL‑17A+ γδT cell activation via the HMGB1‑TLR2/4‑NF‑κB signaling pathways in biliary atresia
                        

产品名称：Tcrδ-KO;Tlr2-KO;Tlr4-KO

研究领域：胆道闭锁,先天性免疫

发表年份：2026 发表杂志：INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

                            
                            High-salt diet promotes atopic dermatitis by partially enhancing intestinal SGK1/ENaC signaling and destroying gut Lactobacillus-maintained systemic type 1 interferon
                        

产品名称：Sting-Flox;Ifnar1-KO

研究领域：高盐饮食;特应性皮炎;肠-皮肤轴

发表年份：2026 发表杂志：Frontiers in Cellular and Infection Microbiology

                            
                            S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis
                        

产品名称：SOD1-G93A

研究领域：肌萎缩侧索硬化症;渐冻症;翻译后修饰

发表年份：2026 发表杂志：MOLECULAR CELL

                            
                            Tumour-associated high endothelial venules drive portal-specific immune evasion in lymph nodes via ALOX12
                        

产品名称：Chst4-CreERT2-2A-tdTomato; R26-CAG-LSL-SP-TATK-mCherry-NLS;R26-CAG-LSL-SP-TATK-mCherry-NLS/Chst4-creert2

研究领域：肿瘤转移;高内皮静脉;肿瘤

发表年份：2026 发表杂志：Nature Communications

                            
                            BCAT1 inhibits crotonate-related epigenetic modulation of metabolic genes in tumor-associated macrophages to counter immunosuppression
                        

产品名称：Bcat1-Flox;Bcat1-KO(2)

研究领域：肝细胞癌;肿瘤;肿瘤相关巨噬细胞

发表年份：2026 发表杂志：Nature Communications

                            
                            Targeting UXS1-Dependent Glucuronate Detoxification Potentiates Metformin's Anti-Tumor Efficacy in Lung Adenocarcinoma
                        

产品名称：Kras-G12D

研究领域：肺腺癌;肿瘤;二甲双胍

发表年份：2026 发表杂志：Advanced Science

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Fuzheng Huayu formula attenuates ductular reaction and liver fibrosis potentially through suppressing Gli1 pathway

Identification of biomarkers associated with pathological dynamic progression in dystrophinopathies

Bacteroides thetaiotaomicron Improves Colorectal Cancer Prognosis by Remodeling the Immune Microenvironment

Therapeutic pressure drives the evolution of a protective ecotype characterized by AR-loss-induced senescence in prostate cancer

IL‑17A+ γδT cell activation via the HMGB1‑TLR2/4‑NF‑κB signaling pathways in biliary atresia

High-salt diet promotes atopic dermatitis by partially enhancing intestinal SGK1/ENaC signaling and destroying gut Lactobacillus-maintained systemic type 1 interferon

S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis

Tumour-associated high endothelial venules drive portal-specific immune evasion in lymph nodes via ALOX12

BCAT1 inhibits crotonate-related epigenetic modulation of metabolic genes in tumor-associated macrophages to counter immunosuppression

Targeting UXS1-Dependent Glucuronate Detoxification Potentiates Metformin's Anti-Tumor Efficacy in Lung Adenocarcinoma

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