历年文献基因敲除小鼠_转基因小鼠定制

                            
                            Targeting TMED4 enhances CD8+ T cell function and CAR T cell efficacy in solid tumors through the IRE1α-autophagy axis
                        

产品名称：C57BL/6

研究领域：实体瘤;免疫;自噬

发表年份：2026 发表杂志：Science Advances

                            
                            Cell surface thiols mediated efficient bladder instillation for intravesical LRG1 silencing and vascular normalization in bladder cancer
                        

产品名称：Lrg1-KO

研究领域：膀胱癌;膀胱灌注;RNA干扰递送

发表年份：2026 发表杂志：CHEMICAL ENGINEERING JOURNAL

                            
                            Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis
                        

产品名称：Ndufa13-Flox;Myh6-CreERtam

研究领域：心脏再生;心肌细胞增殖;糖酵解;细胞周期

发表年份：2026 发表杂志：INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

                            
                            Preclinical evaluation of a fluorinated bifendate derivative in triple-negative breast cancer: integrated in vitro and in vivo evidence of antitumor activity
                        

产品名称：BALB/c nude

研究领域：三阴性乳腺癌;抗肿瘤

发表年份：2026 发表杂志：BMC CANCER

                            
                            Hepatitis C virus inhibits the E2F2/PI3K/AKT signaling pathway through miR-378b and leads to glycolipid metabolism disorders in the liver
                        

产品名称：hCD81/hOCLN

研究领域：丙型肝炎;糖脂代谢紊乱;病毒性肝病

发表年份：2026 发表杂志：MOLECULAR BIOLOGY REPORTS

                            
                            Skeletal-muscle-targeted non-viral delivery of full-length DMD mRNA for Duchenne muscular dystrophy
                        

产品名称：Dmd-Q995X

研究领域：杜氏肌营养不良症

发表年份：2026 发表杂志：Nature Biomedical Engineering

                            
                            JMJD3-driven epigenetic reprogramming of p16INK4a-positive cells promotes tendon regeneration
                        

产品名称：Cdkn2a-Luc-2A-tdTomato-2A-CreERT2(p16-Luc-2A-tdTomato-2A-CreERT2);Kdm6b-Flox

研究领域：肌腱愈合

发表年份：2026 发表杂志：Bone Research

                            
                            Targeting the SIRT6–TDO2/KYNA–mTOR axis rescues synaptic and cognitive deficits in fetal growth restriction offspring
                        

产品名称：Camk2a-Cre

研究领域：胎儿生长受限

发表年份：2026 发表杂志：EXPERIMENTAL AND MOLECULAR MEDICINE

                            
                            Targeting DNGR-1 with Fangchinoline Elevates Dendritic Cell Antigen Cross-Presentation-Mediated Antitumor Immunity in Melanoma
                        

产品名称：Itgax-2A-tdTomato-2A-DTR;Clec9a-KO

研究领域：黑色素瘤;树突状细胞;抗原交叉呈递;抗肿瘤免疫

发表年份：2026 发表杂志：Advanced Science

                            
                            A hypothalamic VMPO-supraoptic vasopressin circuit mediates procalcitonin-induced fluid imbalance
                        

产品名称：ROSA-LSL-EGFP

研究领域：降钙素原;体液失衡;加压素神经环路

发表年份：2026 发表杂志：Cell Reports

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Targeting TMED4 enhances CD8+ T cell function and CAR T cell efficacy in solid tumors through the IRE1α-autophagy axis

Cell surface thiols mediated efficient bladder instillation for intravesical LRG1 silencing and vascular normalization in bladder cancer

Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Preclinical evaluation of a fluorinated bifendate derivative in triple-negative breast cancer: integrated in vitro and in vivo evidence of antitumor activity

Hepatitis C virus inhibits the E2F2/PI3K/AKT signaling pathway through miR-378b and leads to glycolipid metabolism disorders in the liver

Skeletal-muscle-targeted non-viral delivery of full-length DMD mRNA for Duchenne muscular dystrophy

JMJD3-driven epigenetic reprogramming of p16INK4a-positive cells promotes tendon regeneration

Targeting the SIRT6–TDO2/KYNA–mTOR axis rescues synaptic and cognitive deficits in fetal growth restriction offspring

Targeting DNGR-1 with Fangchinoline Elevates Dendritic Cell Antigen Cross-Presentation-Mediated Antitumor Immunity in Melanoma

A hypothalamic VMPO-supraoptic vasopressin circuit mediates procalcitonin-induced fluid imbalance

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