历年文献基因敲除小鼠_转基因小鼠定制

                            
                            Probiotic interventions maintain intestinal barrier function and alleviate necrotizing enterocolitis by inhibiting ferroptosis in intestinal PMN-MDSCs
                        

产品名称：Gpx4-Flox

研究领域：益生菌;坏死性小肠结肠炎;肠屏障功能;铁死亡;新生儿肠道免疫

发表年份：2026 发表杂志：Cell Death & Disease

                            
                            The mechanistic role of secretin and its receptor in regulating hippocampal dentate gyrus glutamatergic neuronal activity in methamphetamine addiction
                        

产品名称：Sctr-2A-Cre

研究领域：甲基苯丙胺成瘾;促胰液素/受体;谷氨酸能神经元;成瘾神经环路;神经肽调控

发表年份：2026 发表杂志：BIOCHEMICAL PHARMACOLOGY

                            
                            Adipokine IL-11/IL-11Ra constrains sphingolipid metabolism to limit the thermogenic capacity of beige adipocytes
                        

产品名称：IL11Ra-KO

研究领域：脂肪因子;鞘脂代谢;米色脂肪;适应性产热;脂肪可塑性

发表年份：2026 发表杂志：Cell Metabolism

                            
                            Galactosylated LNP-mediated hepatic Sam68 silencing improves glucose homeostasis in diabetes by suppressing gluconeogenesis
                        

产品名称：db/db

研究领域：糖尿病;半乳糖化脂质纳米粒;肝糖异生;葡萄糖稳态

发表年份：2026 发表杂志：JOURNAL OF NANOBIOTECHNOLOGY

                            
                            Photocontrollable Electrochemical Molecular Probe for the Detection of Cu2+ in Brain Dialysates of Alzheimer’s Disease Mice
                        

产品名称：AD model

研究领域：光控电化学探针;阿尔茨海默病;脑微透析;神经化学检测

发表年份：2026 发表杂志：ACS Sensors

                            
                            Saikosaponins aggravate mitochondrial damage and senescence of cholangiocyte in cholestatic liver diseases by inhibiting protective autophagy
                        

产品名称：Abcb4-KO

研究领域：柴胡皂苷;胆汁淤积性肝病;胆管细胞衰老;线粒体损伤;保护性自噬抑制;中药潜在毒性

发表年份：2026 发表杂志：PHYTOMEDICINE

                            
                            The IC-SNc neural circuit mediates prepulse inhibition deficits in MPTP-induced Parkinson’s disease male mice
                        

产品名称：DAT-Cre

研究领域：帕金森病，感觉运动门控，MPTP小鼠模型，听觉惊跳反射

发表年份：2026 发表杂志：npj Parkinsons Disease

                            
                            SAHH Deficiency Decreases Stability of Atherosclerotic Plaque and Induces VSMC Phenotype Switching via Epigenetic Upregulation of KLF4 and OCT4
                        

产品名称：Tagln-Cre;LyzM-Cre

研究领域：SAHH缺陷;动脉粥样硬化斑块稳定性;血管平滑肌细胞;表观遗传调控

发表年份：2026 发表杂志：ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

                            
                            Down-Regulation of miR-149-5p Regulates Colon Mucosal Epithelial Cell Function by Targeting IGF2BP1 to Alleviate Irritable Bowel Syndrome
                        

产品名称：miR-149-5p-KO

研究领域：肠易激综合征;结肠黏膜上皮屏障;肠道微RNA

发表年份：2026 发表杂志：NEUROGASTROENTEROLOGY AND MOTILITY

                            
                            CircCDK6 Regulates Stemness Maintenance and Cisplatin Resistance in Lung Adenocarcinoma via the Wnt/β-Catenin Signaling Pathway
                        

产品名称：BALB/c nude

研究领域：肺腺癌;肿瘤干性维持;顺铂耐药;化疗抵抗

发表年份：2026 发表杂志：Cancer Management and Research

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Probiotic interventions maintain intestinal barrier function and alleviate necrotizing enterocolitis by inhibiting ferroptosis in intestinal PMN-MDSCs

The mechanistic role of secretin and its receptor in regulating hippocampal dentate gyrus glutamatergic neuronal activity in methamphetamine addiction

Adipokine IL-11/IL-11Ra constrains sphingolipid metabolism to limit the thermogenic capacity of beige adipocytes

Galactosylated LNP-mediated hepatic Sam68 silencing improves glucose homeostasis in diabetes by suppressing gluconeogenesis

Photocontrollable Electrochemical Molecular Probe for the Detection of Cu2+ in Brain Dialysates of Alzheimer’s Disease Mice

Saikosaponins aggravate mitochondrial damage and senescence of cholangiocyte in cholestatic liver diseases by inhibiting protective autophagy

The IC-SNc neural circuit mediates prepulse inhibition deficits in MPTP-induced Parkinson’s disease male mice

SAHH Deficiency Decreases Stability of Atherosclerotic Plaque and Induces VSMC Phenotype Switching via Epigenetic Upregulation of KLF4 and OCT4

Down-Regulation of miR-149-5p Regulates Colon Mucosal Epithelial Cell Function by Targeting IGF2BP1 to Alleviate Irritable Bowel Syndrome

CircCDK6 Regulates Stemness Maintenance and Cisplatin Resistance in Lung Adenocarcinoma via the Wnt/β-Catenin Signaling Pathway

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