历年文献基因敲除小鼠_转基因小鼠定制

                            
                            The Ca2+ sensor STIM1 promotes neuronal ferroptosis by regulating iron homeostasis to exacerbate brain injury after intracerebral hemorrhage
                        

产品名称：Stim1-Flox; Nestin-Cre

研究领域：神经科学; 脑出血; 铁死亡

发表年份：2026 发表杂志：Cell Reports Medicine

                            
                            GPR35 protects against reperfusion injury in ischemic stroke by binding with the CR2 domain of Raf1
                        

产品名称：Gpr35-Flox

研究领域：脑卒中; 神经保护; 信号转导

发表年份：2026 发表杂志：Journal of Neuroinflammation

                            
                            Apolipoprotein J-mediated hepato-renal crosstalk drives renal injury in chronic kidney disease
                        

产品名称：Clu-Flox/Alb-Cre; Clu-Flox/Cdh16-Cre-Tg

研究领域：肝-肾轴; 慢性肾病; 载脂蛋白

发表年份：2026 发表杂志：FREE RADICAL BIOLOGY AND MEDICINE

                            
                            BACH2 alleviates immune checkpoint inhibitors-induced cardiac pyroptosis via transcriptionally promoting GRSF1
                        

产品名称：R26-CAG-LSL-Bach2-m-WPRE-pA

研究领域：心脏肿瘤学; 免疫治疗不良反应; 细胞焦亡

发表年份：2026 发表杂志：Clinical and Translational Medicine

                            
                            Loss of GPR133 Promotes Enzalutamide Resistance in Prostate Cancer by Upregulating HSD3B1 and Intratumoral Androgen Synthesis
                        

产品名称：BALB/c Nude

研究领域：前列腺癌; 耐药机制; 雄激素合成

发表年份：2026 发表杂志：PROSTATE

                            
                            A MERTK-Targeting Antibody-Drug Conjugate Selectively Depletes M2 Tumor-Associated Macrophages and MERTK-Expressing Cancer Cells
                        

产品名称：MC38-HM; hMERTK

研究领域：肿瘤免疫; M2肿瘤相关巨噬细胞

发表年份：2026 发表杂志：CANCER RESEARCH

                            
                            Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16–CXCR6 signaling for potent antitumor response
                        

产品名称：Cxcr6-Flox; Cd3e-IRES-Cre

研究领域：肿瘤; 三重靶向策略

发表年份：2026 发表杂志：Nature Communications

                            
                            Downregulation of neuronal DRD2 drives microglia synaptic pruning and results in cognitive deficits by promoting CCL2 release in a rat model of chronic migraine
                        

产品名称：Drd2-KO

研究领域：慢性偏头痛; 小胶质细胞

发表年份：2026 发表杂志：JOURNAL OF HEADACHE AND PAIN

                            
                            PPARγ in microglia helps protect adolescent male mice from harmful effects of stress during early development
                        

产品名称：Pparg-Flox; Cx3cr1-CreERT2

研究领域：小胶质细胞; 突触可塑性

发表年份：2026 发表杂志：BRAIN BEHAVIOR AND IMMUNITY

                            
                            UHRF1 deficiency exacerbates intestinal inflammation by epigenetic modulation of NPY1R gene methylation
                        

产品名称：Uhrf1-Flox

研究领域：甲基化; 炎症性肠病（

发表年份：2026 发表杂志：JCI Insight

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The Ca2+ sensor STIM1 promotes neuronal ferroptosis by regulating iron homeostasis to exacerbate brain injury after intracerebral hemorrhage

GPR35 protects against reperfusion injury in ischemic stroke by binding with the CR2 domain of Raf1

Apolipoprotein J-mediated hepato-renal crosstalk drives renal injury in chronic kidney disease

BACH2 alleviates immune checkpoint inhibitors-induced cardiac pyroptosis via transcriptionally promoting GRSF1

Loss of GPR133 Promotes Enzalutamide Resistance in Prostate Cancer by Upregulating HSD3B1 and Intratumoral Androgen Synthesis

A MERTK-Targeting Antibody-Drug Conjugate Selectively Depletes M2 Tumor-Associated Macrophages and MERTK-Expressing Cancer Cells

Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16–CXCR6 signaling for potent antitumor response

Downregulation of neuronal DRD2 drives microglia synaptic pruning and results in cognitive deficits by promoting CCL2 release in a rat model of chronic migraine

PPARγ in microglia helps protect adolescent male mice from harmful effects of stress during early development

UHRF1 deficiency exacerbates intestinal inflammation by epigenetic modulation of NPY1R gene methylation

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