R26-CreERT2

将 CAG-CreERT2-Rox-WPRE-Rox-polyA插入到小鼠Rosa26基因中。 他莫昔芬诱导后，多组织表达Cre重组酶，当与含有loxP位点侧翼序列的菌株杂交时，cre介导的重组会介导后代多组织侧翼序列的缺失。该品系多组织出现泄露。

Fig1. Detection of tdTomato(red) in various tissues of R26CreERT2/+; Rosa26tdTomato/+ mice by fluorescence assay. Expression tissues include: brain, liver, stomach, thymus, pancreas, colon, heart, kidney and spleen. (For more detailed information please contact our technical advisor.) 

Fig2. CreERT2-mediated recombination in peripheral blood of R26CreERT2/+; Rosa26tdTomato/+ mice.

Fig3. CreERT2-mediated recombination in pancreas of  R26CreERT2/+; Rosa26tdTomato/+ mice.

Fig2. Detection of tdTomato(red) in various tissues of R26^CreERT2/+;Rosa26 ^tdTomato/+ mouse. 

Tissues with cellular expression after tamoxifen induction include: brain, eye, heart, lung, liver, stomach, adrenal gland, pituitary gland, salivary gland, brown adipose tissue, kidney, large intestine, small intestine, spleen, reproductive system, muscle, skin, pancreas, thymus, dorsal root ganglion, and sciatic nerve.

Cellular leaky expression is also present in the brain, eye, heart, lung, liver, stomach, adrenal gland, pituitary gland, salivary gland, brown adipose tissue, kidney, large intestine, small intestine, spleen, reproductive system, muscle, skin, pancreas, thymus, dorsal root ganglion, and sciatic nerve.

Mouse age: 62 days; Female. (For more detailed information please contact our technical advisor.)