Ighm/Ighd-KO
品系全名
C57BL/6Smoc-Ighmem1Ighdem1Smoc
目录号
NM-KO-200610
品系状态
活体
品系描述
敲除Ighm基因 exon 1-6和 Ighd基因exon 1-5，建立Ighm、Ighd双基因敲除小鼠模型。该纯合子小鼠缺乏成熟的B细胞，可以作为B细胞免疫缺陷的动物模型。
应用领域：免疫相关
*使用本品系发表的文献需注明: Ighm/Ighd-KO mice (Cat. NO. NM-KO-200610) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. Confirmation of Ighm knockout and B cell development in blood in Ighm/Ighd-KO mice by FACS.
Fig2. T cell and NK cell lineages development in blood in Ighm/Ighd-KO mice by FACS.
Fig3. In vivo anti-tumor efficacy in Ighm/Ighd-KO mice bearing MC38 syngeneic tumors.
Fig4. The impact of B cell depeltion on the anti-tumor efficacy in Ighm/Ighd-KO mice bearing mPA6115 tumors (GEMM-derived homograft).
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