Abcb4-KO(FVB)

品系全名

FVB-Abcb4em1Smoc

目录号

NM-KO-200584

品系状态

胚胎冻存

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基因信息

基因名
Abcb4

品系描述

敲除Abcb4基因exon 3-4,建立Abcb4基因敲除小鼠模型。
应用领域:胆汁等疾病相关研究

疾病预测

胆囊炎
Cholecystitis
胆汁淤积
Cholestasis
肝内胆汁淤积
Intrahepatic Cholestasis
肝细胞癌
Hepatocellular Carcinoma
原发性硬化性胆管炎
Primary Sclerosing Cholangitis

验证数据

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Fig1. Serum biochemistry of Abcb4-KO mice (n=3 female and 3 male).

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Fig2. Significant bile duct hyperplasia and interstitial focal cell infiltration were observed in the liver of Abcb4-KO mice.

(A) Liver were collected from FVB wild-type (+/+) and Abcb4-KO mice, and analyzed by HE staining. (B) Pathological analysis of the liver in Abcb4-KO mice.

image.png

Fig3. Collagen fiber hyperplasia were observed in the liver of Abcb4-KO mice.

(A) Liver were collected from FVB wild-type (+/+) and Abcb4-KO mice, and analyzed by Masson staining. (B) Quantification of the Collagen volume fraction (CVF) .


发表文献

A novel role for interleukin 32 in cholestasis
来源杂志:Clinical and Translational Medicine


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