模型资源
- 成品模型
- 工具小鼠
- Find Cre 工具鼠
- 报告基因工具鼠
- 荧光示踪小鼠
- 其他报告基因工具鼠
- 基因调控工具鼠
- 四环素调控工具鼠
- 疾病小鼠(U-DMbase®)
- 自发肿瘤小鼠模型
- 罕见病小鼠模型
- 传染病研究模型
- 神经系统疾病模型
- 代谢心血管疾病模型
- 自身免疫疾病模型
- 免疫学研究小鼠
- 免疫靶点人源化小鼠
- 免疫缺陷小鼠
- 免疫细胞标记小鼠
- 细胞因子示踪小鼠
- 免疫细胞剔除小鼠
- 人源化小鼠
- 肿瘤靶点
- 免疫检查点
- 补体系统靶点
- 细胞因子
- 细胞因子受体
- 代谢靶点
- 病毒感染受体
- 其他靶点
- 常规基因修饰模型
- 全身敲除小鼠
- 条件性敲除小鼠
- 过表达小鼠
- 点突变小鼠
- 敲入小鼠
- 大鼠模型资源库
- 免疫缺陷大鼠
- 人源化大鼠
- 荧光示踪大鼠
- 疾病模型
- 工具大鼠
- 细胞系
- 其他细胞系
- 原代细胞系
- 人源化细胞系
- 荧光细胞系
- 野生型细胞系
- 常规小鼠品系
- 远交系(封闭群)小鼠
- 近交系小鼠
BALB/c Nude
品系全名
BALB/c Nude
目录号
SM-014
品系状态
活体
品系描述
验证数据

Fig1. Body weight growth curve of BALB/c Nude (n=780)

Fig2. Complete deletion of T, B cells of BALB/c Nude.

Fig3. Subcutaneous xenograft tumor growth in BALB/c Nude.

Fig4. Blood routine tests in BALB/c Nude.

Fig5. Blood biochemistry in BALB/c Nude.
Table 1. BALB/c Nude xenograft cell lines

发表文献 73篇
1.
SMAD4 Palmitoylation Drives a Metabolic-Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer
发表年份:2026
来源杂志:Advanced Science
2.
Targeting the FOSL1/IKKα positive feedback loop attenuates glioblastoma malignancy via suppression of NF-κB signaling
发表年份:2026
来源杂志:Theranostics
3.
Loss of TFAM Accelerates Pentose Phosphate Pathway by Unleashing G6PD Oligomerization to Drive Hepatocarcinogenesis
发表年份:2026
来源杂志:CANCER LETTERS
4.
Melanoma exosomal miR-708-5p promotes macrophage M2 polarization and cancer metastasis
发表年份:2026
来源杂志:Cell Death & Disease
5.
GSH-Activated Cu-TCPP(Zn)/Ti3C2Tx Nanozymes for Fluorescence Imaging-Guided Synergistic Photodynamic/Chemodynamic Therapy of Oral Squamous Cell Carcinoma
发表年份:2026
来源杂志:ACS Applied Materials & Interfaces
6.
Modulating tumor-associated macrophages through APP-CD74 blockade with IL4R-exosomes synergizes with PD-1 inhibition in gastric cancer
发表年份:2026
来源杂志:npj Precision Oncology
7.
ADCY7 dictates N-cadherin stability to inhibit HCC metastasis
发表年份:2026
来源杂志:JHEP Reports
8.
MD2 suppresses anaplastic thyroid Cancer progression by reprogramming macrophages via USP15-mediated FHL1 Deubiquitination
发表年份:2026
来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY
9.
KCTD15 Enhances Stem Cell‐Like Properties and Promotes Triple‐Negative Breast Cancer Progression Through KLF4/β‐Catenin Signaling
发表年份:2026
来源杂志:FASEB JOURNAL
10.
FOXA2/ALDOB axis modulation of fatty acid beta-oxidation influences irinotecan resistance in colorectal cancer
发表年份:2026
来源杂志:BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
11.
Calycosin exerts anti-glioblastoma effects by inhibiting GPX-4 to promote oxidative stress
发表年份:2026
来源杂志:BRAIN RESEARCH BULLETIN
12.
Loss of GPR133 Promotes Enzalutamide Resistance in Prostate Cancer by Upregulating HSD3B1 and Intratumoral Androgen Synthesis
发表年份:2026
来源杂志:PROSTATE
13.
Multi-omics analysis identifies BUB1B as a cell cycle–related driver of bladder cancer progression
发表年份:2026
来源杂志:World Journal of Surgical Oncology
14.
CEACAM6 silencing suppresses tumour growth and sensitises cholangiocarcinoma to cisplatin
发表年份:2026
来源杂志:Clinical and Translational Discovery
15.
RNA target-independent non-canonical activation (RINCA) of Cas13 trans-nuclease activity
发表年份:2025
来源杂志:Science Bulletin
16.
Targeting Hyperglycemic Bone Pre-Metastatic Niche for Breast Cancer Bone Metastasis Therapy
发表年份:2025
来源杂志:Advanced Science
17.
Malignant Hepatoblast-Like Cells Sustain Stemness via IGF2-Dependent Cholesterol Accumulation in Hepatoblastoma
发表年份:2025
来源杂志:Advanced Science
18.
A Self-Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple-Negative Breast Cancer Therapy
发表年份:2025
来源杂志:Advanced Science
19.
NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis
发表年份:2025
来源杂志:Advanced Science
20.
FAM50A drives breast cancer brain metastasis through interaction with C9ORF78 to enhance ʟ-asparagine production
发表年份:2025
来源杂志:Science Advances
21.
Targeting the ac4C ‘Writer’ NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells
发表年份:2025
来源杂志:Cell Death & Disease
22.
Sino-C, a novel sinomenine derivative, induces cell death by disrupting cholesterol homeostasis in colorectal cancer cells
发表年份:2025
来源杂志:ACTA PHARMACOLOGICA SINICA
23.
Unraveling the secrets of UBE2S in endometrial cancer: Potential targets for diagnosis, prognostic assessment, and ferroptosis therapy
发表年份:2025
来源杂志:CELLULAR SIGNALLING
24.
The lysosomal cysteine protease cathepsin L promotes stemness and multidrug resistance of non-small cell lung cancer by targeting HGF activator
发表年份:2025
来源杂志:MOLECULAR AND CELLULAR BIOCHEMISTRY
25.
APOBEC3B-driven mutations negatively regulated by P53 promote tumor progression and immunosuppressive microenvironment in prostate cancer
发表年份:2025
来源杂志:MOLECULAR AND CELLULAR BIOCHEMISTRY
26.
BRAP Promotes the Tumorigenesis of Hepatocellular Carcinoma by Corrupting Cancer Cell Cycle Regulation and Enhancing Immune Evasion
发表年份:2025
来源杂志:Journal of Hepatocellular Carcinoma
27.
VDAC1 as prognostic marker and therapeutic target in lung adenocarcinoma: a study integrating bioinformatics and experimental validation
发表年份:2025
来源杂志:Discover Oncology
28.
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer
发表年份:2025
来源杂志:Signal Transduction and Targeted Therapy
29.
BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism
发表年份:2024
来源杂志:Cell Host & Microbe
30.
The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis
发表年份:2024
来源杂志:Nature Microbiology
31.
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation
发表年份:2024
来源杂志:DRUG RESISTANCE UPDATES
32.
Effect of Bioactive Black Phosphorus Nanomaterials on Cancer-Associated Fibroblast Heterogeneity in Pancreatic Cancer
发表年份:2024
来源杂志:ACS Nano
33.
Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma
发表年份:2024
来源杂志:Nature Communications
34.
Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple-Negative Breast Cancer Progression via Epigenetic Modulation of SREBP1-Regulated Cholesterol Metabolism
发表年份:2024
来源杂志:Advanced Science
35.
Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis
发表年份:2024
来源杂志:Advanced Science
36.
A STT3A-dependent PD-L1 glycosylation modification mediated by GMPS drives tumor immune evasion in hepatocellular carcinoma
发表年份:2024
来源杂志:CELL DEATH AND DIFFERENTIATION
37.
Cuproptosis and Serine Metabolism Blockade Triggered by Copper-Based Prussian Blue Nanomedicine for Enhanced Tumor Therapy
发表年份:2024
来源杂志:Small
38.
LncRNA SNHG1 facilitates colorectal cancer cells metastasis by recruiting HNRNPD protein to stabilize SERPINA3 mRNA
发表年份:2024
来源杂志:CANCER LETTERS
39.
The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment
发表年份:2024
来源杂志:Cell Death & Disease
40.
SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1
发表年份:2024
来源杂志:Cell Reports
41.
Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma
发表年份:2024
来源杂志:Journal of Translational Medicine
42.
Quercetin Attenuates Cancer-Associated Fibroblast Activation via Tumor-Stromal Interactions and Demonstrates Its Clinical Value in Pancreatic Cancer
发表年份:2024
来源杂志:JOURNAL OF FOOD BIOCHEMISTRY
43.
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
发表年份:2023
来源杂志:Molecular Cancer
44.
Targeted therapy of central nervous system acute lymphoblastic leukemia with an integrin α6-targeted self-assembling proapoptotic nanopeptide
发表年份:2023
来源杂志:Engineering
45.
Epitranscriptic regulation of HRAS by N6-methyladenosine drives tumor progression
发表年份:2023
来源杂志:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
46.
Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1
发表年份:2022
来源杂志:Nature Communications
47.
Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
发表年份:2022
来源杂志:JCI Insight
48.
Flower-like Composite Material Delivery of Co-Packaged Lenvatinib and Bufalin Prevents the Migration and Invasion of Cholangiocarcinoma
发表年份:2022
来源杂志:Nanomaterials
49.
Long non-coding RNA TDRG1 aggravates colorectal cancer stemness by binding with miR-873-5p to upregulate PRKAR2
发表年份:2022
来源杂志:ENVIRONMENTAL TOXICOLOGY
50.
CtBP proteins transactivate matrix metalloproteinases and proinflammatory cytokines to mediate the pathogenesis of abdominal aortic aneurysm
发表年份:2022
来源杂志:EXPERIMENTAL CELL RESEARCH
51.
Sanguinarine Represses the Growth and Metastasis of Non-small Cell Lung Cancer by Facilitating Ferroptosis
发表年份:2022
来源杂志:CURRENT PHARMACEUTICAL DESIGN
52.
Tripartite Motif Containing 26 is a Positive Predictor for
Endometrial Carcinoma Patients and Regulates Cell Survival in Endometrial
Carcinoma
发表年份:2022
来源杂志:HORMONE AND METABOLIC RESEARCH
53.
RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA
发表年份:2021
来源杂志:Clinical and Translational Medicine
54.
Tumour-Targeted and Redox-Responsive Mesoporous Silica Nanoparticles for Controlled Release of Doxorubicin and an siRNA Against Metastatic Breast Cancer
发表年份:2021
来源杂志:International Journal of Nanomedicine
55.
Enzalutamide-Induced Upregulation of PCAT6 Promotes Prostate Cancer Neuroendocrine Differentiation by Regulating miR-326/HNRNPA2B1 Axis
发表年份:2021
来源杂志:Frontiers in Oncology
56.
Downregulated F-Box/LRR-Repeat Protein 7 Facilitates Pancreatic Cancer Metastasis by Regulating Snail1 for Proteasomal Degradation
发表年份:2021
来源杂志:Frontiers in Genetics
57.
RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination
发表年份:2021
来源杂志:ENVIRONMENTAL TOXICOLOGY
58.
Fat1 suppresses the tumor-initiating ability of nonsmall cell lung cancer cells by promoting Yes-associated protein 1 nuclear-cytoplasmic translocation
发表年份:2021
来源杂志:ENVIRONMENTAL TOXICOLOGY
59.
Long non‑coding RNA LINC01224 promotes cell proliferation and inhibits apoptosis by regulating AKT3 expression via targeting miR‑485‑5p in endometrial carcinoma
发表年份:2021
来源杂志:ONCOLOGY REPORTS
60.
Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
发表年份:2021
来源杂志:IMMUNOLOGICAL INVESTIGATIONS
61.
Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR‑145‑5p/TOP2A axis
发表年份:2021
来源杂志:Molecular Medicine Reports
62.
Upregulated osteoprotegerin expression promotes lung cancer cell invasion by increasing miR‑20a expression
发表年份:2021
来源杂志:Experimental and Therapeutic Medicine
63.
The p53-inducible CLDN7 regulates colorectal tumorigenesis and has prognostic significance
发表年份:2020
来源杂志:NEOPLASIA
64.
GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway
发表年份:2019
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
65.
Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities
发表年份:2019
来源杂志:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
66.
Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis
发表年份:2019
来源杂志:INTERNATIONAL JOURNAL OF ONCOLOGY
67.
The miRNA-149-5p/MyD88 axis is responsible for ursolic acid-mediated attenuation of the stemness and chemoresistance of non-small cell lung cancer cells
发表年份:2019
来源杂志:ENVIRONMENTAL TOXICOLOGY
68.
Elevated MIR100HG promotes colorectal cancer metastasis and is associated with poor prognosis
发表年份:2019
来源杂志:Oncology Letters
69.
miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer
发表年份:2018
来源杂志:Journal of Molecular Cell Biology
70.
Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles
发表年份:2018
来源杂志:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
71.
Targeting endogenous DLK1 exerts antitumor effect on hepatocellular carcinoma through initiating cell differentiation
发表年份:2016
来源杂志:Oncotarget
72.
Glyoxalase-1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose-Derived Stem Cells in Streptozotocin-Induced Diabetic Mice Model of Critical Limb Ischemia
发表年份:2016
来源杂志:Stem Cells Translational Medicine
73.
Disruption and inactivation of the PP2A complex promotes the proliferation and angiogenesis of hemangioma endothelial cells through activating AKT and ERK
发表年份:2015
来源杂志:Oncotarget
相关品系
你也可能感兴趣
Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
查看Cre-lox系统介绍及使用汇总
你一定听说过Cre-lox重组系统,无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点,如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统,可以在特定细胞、组织或整个生物体,甚至在特定时间点敲除或表达某个基因,实现对特定基因的时空特异性操作,这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。
查看
