BALB/c Nude

品系全名

BALB/c Nude

目录号

SM-014

品系状态

活体

导出PDF

品系描述

BALB/c背景下Foxn1基因纯合突变,裸鼠是快速生长的肿瘤细胞系的理想宿主,但部分细胞系在裸鼠上难以成瘤,如血液瘤细胞系、乳腺癌细胞系、原代细胞等。裸鼠无毛,更容易直观的评估皮下肿瘤的生长情况。

验证数据

image.png

Fig1. Body weight growth curve of BALB/c Nude (n=780)

image.png

Fig2. Complete deletion of T, B cells of BALB/c Nude. 

image.png

Fig3. Subcutaneous xenograft tumor growth in BALB/c Nude. 

image.png

Fig4. Blood routine tests in BALB/c Nude.

image.png

Fig5. Blood biochemistry in BALB/c Nude.

Table 1. BALB/c Nude xenograft cell lines

image.png


发表文献 73篇

1. SMAD4 Palmitoylation Drives a Metabolic-Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer
发表年份:2026 来源杂志:Advanced Science

2. Targeting the FOSL1/IKKα positive feedback loop attenuates glioblastoma malignancy via suppression of NF-κB signaling
发表年份:2026 来源杂志:Theranostics

3. Loss of TFAM Accelerates Pentose Phosphate Pathway by Unleashing G6PD Oligomerization to Drive Hepatocarcinogenesis
发表年份:2026 来源杂志:CANCER LETTERS

4. Melanoma exosomal miR-708-5p promotes macrophage M2 polarization and cancer metastasis
发表年份:2026 来源杂志:Cell Death & Disease

5. GSH-Activated Cu-TCPP(Zn)/Ti3C2Tx Nanozymes for Fluorescence Imaging-Guided Synergistic Photodynamic/Chemodynamic Therapy of Oral Squamous Cell Carcinoma
发表年份:2026 来源杂志:ACS Applied Materials & Interfaces

6. Modulating tumor-associated macrophages through APP-CD74 blockade with IL4R-exosomes synergizes with PD-1 inhibition in gastric cancer
发表年份:2026 来源杂志:npj Precision Oncology

7. ADCY7 dictates N-cadherin stability to inhibit HCC metastasis
发表年份:2026 来源杂志:JHEP Reports

8. MD2 suppresses anaplastic thyroid Cancer progression by reprogramming macrophages via USP15-mediated FHL1 Deubiquitination
发表年份:2026 来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY

9. KCTD15 Enhances Stem Cell‐Like Properties and Promotes Triple‐Negative Breast Cancer Progression Through KLF4/β‐Catenin Signaling
发表年份:2026 来源杂志:FASEB JOURNAL

10. FOXA2/ALDOB axis modulation of fatty acid beta-oxidation influences irinotecan resistance in colorectal cancer
发表年份:2026 来源杂志:BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

11. Calycosin exerts anti-glioblastoma effects by inhibiting GPX-4 to promote oxidative stress
发表年份:2026 来源杂志:BRAIN RESEARCH BULLETIN

12. Loss of GPR133 Promotes Enzalutamide Resistance in Prostate Cancer by Upregulating HSD3B1 and Intratumoral Androgen Synthesis
发表年份:2026 来源杂志:PROSTATE

13. Multi-omics analysis identifies BUB1B as a cell cycle–related driver of bladder cancer progression
发表年份:2026 来源杂志:World Journal of Surgical Oncology

14. CEACAM6 silencing suppresses tumour growth and sensitises cholangiocarcinoma to cisplatin
发表年份:2026 来源杂志:Clinical and Translational Discovery

15. RNA target-independent non-canonical activation (RINCA) of Cas13 trans-nuclease activity
发表年份:2025 来源杂志:Science Bulletin

16. Targeting Hyperglycemic Bone Pre-Metastatic Niche for Breast Cancer Bone Metastasis Therapy
发表年份:2025 来源杂志:Advanced Science

17. Malignant Hepatoblast-Like Cells Sustain Stemness via IGF2-Dependent Cholesterol Accumulation in Hepatoblastoma
发表年份:2025 来源杂志:Advanced Science

18. A Self-Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple-Negative Breast Cancer Therapy
发表年份:2025 来源杂志:Advanced Science

19. NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis
发表年份:2025 来源杂志:Advanced Science

20. FAM50A drives breast cancer brain metastasis through interaction with C9ORF78 to enhance ʟ-asparagine production
发表年份:2025 来源杂志:Science Advances

21. Targeting the ac4C ‘Writer’ NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells
发表年份:2025 来源杂志:Cell Death & Disease

22. Sino-C, a novel sinomenine derivative, induces cell death by disrupting cholesterol homeostasis in colorectal cancer cells
发表年份:2025 来源杂志:ACTA PHARMACOLOGICA SINICA

23. Unraveling the secrets of UBE2S in endometrial cancer: Potential targets for diagnosis, prognostic assessment, and ferroptosis therapy
发表年份:2025 来源杂志:CELLULAR SIGNALLING

24. The lysosomal cysteine protease cathepsin L promotes stemness and multidrug resistance of non-small cell lung cancer by targeting HGF activator
发表年份:2025 来源杂志:MOLECULAR AND CELLULAR BIOCHEMISTRY

25. APOBEC3B-driven mutations negatively regulated by P53 promote tumor progression and immunosuppressive microenvironment in prostate cancer
发表年份:2025 来源杂志:MOLECULAR AND CELLULAR BIOCHEMISTRY

26. BRAP Promotes the Tumorigenesis of Hepatocellular Carcinoma by Corrupting Cancer Cell Cycle Regulation and Enhancing Immune Evasion
发表年份:2025 来源杂志:Journal of Hepatocellular Carcinoma

27. VDAC1 as prognostic marker and therapeutic target in lung adenocarcinoma: a study integrating bioinformatics and experimental validation
发表年份:2025 来源杂志:Discover Oncology

28. Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer
发表年份:2025 来源杂志:Signal Transduction and Targeted Therapy

29. BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism
发表年份:2024 来源杂志:Cell Host & Microbe

30. The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis
发表年份:2024 来源杂志:Nature Microbiology

31. Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation
发表年份:2024 来源杂志:DRUG RESISTANCE UPDATES

32. Effect of Bioactive Black Phosphorus Nanomaterials on Cancer-Associated Fibroblast Heterogeneity in Pancreatic Cancer
发表年份:2024 来源杂志:ACS Nano

33. Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma
发表年份:2024 来源杂志:Nature Communications

34. Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple-Negative Breast Cancer Progression via Epigenetic Modulation of SREBP1-Regulated Cholesterol Metabolism
发表年份:2024 来源杂志:Advanced Science

35. Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis
发表年份:2024 来源杂志:Advanced Science

36. A STT3A-dependent PD-L1 glycosylation modification mediated by GMPS drives tumor immune evasion in hepatocellular carcinoma
发表年份:2024 来源杂志:CELL DEATH AND DIFFERENTIATION

37. Cuproptosis and Serine Metabolism Blockade Triggered by Copper-Based Prussian Blue Nanomedicine for Enhanced Tumor Therapy
发表年份:2024 来源杂志:Small

38. LncRNA SNHG1 facilitates colorectal cancer cells metastasis by recruiting HNRNPD protein to stabilize SERPINA3 mRNA
发表年份:2024 来源杂志:CANCER LETTERS

39. The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment
发表年份:2024 来源杂志:Cell Death & Disease

40. SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1
发表年份:2024 来源杂志:Cell Reports

41. Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma
发表年份:2024 来源杂志:Journal of Translational Medicine

42. Quercetin Attenuates Cancer-Associated Fibroblast Activation via Tumor-Stromal Interactions and Demonstrates Its Clinical Value in Pancreatic Cancer
发表年份:2024 来源杂志:JOURNAL OF FOOD BIOCHEMISTRY

43. Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
发表年份:2023 来源杂志:Molecular Cancer

44. Targeted therapy of central nervous system acute lymphoblastic leukemia with an integrin α6-targeted self-assembling proapoptotic nanopeptide
发表年份:2023 来源杂志:Engineering

45. Epitranscriptic regulation of HRAS by N6-methyladenosine drives tumor progression
发表年份:2023 来源杂志:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

46. Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1
发表年份:2022 来源杂志:Nature Communications

47. Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
发表年份:2022 来源杂志:JCI Insight

48. Flower-like Composite Material Delivery of Co-Packaged Lenvatinib and Bufalin Prevents the Migration and Invasion of Cholangiocarcinoma
发表年份:2022 来源杂志:Nanomaterials

49. Long non-coding RNA TDRG1 aggravates colorectal cancer stemness by binding with miR-873-5p to upregulate PRKAR2
发表年份:2022 来源杂志:ENVIRONMENTAL TOXICOLOGY

50. CtBP proteins transactivate matrix metalloproteinases and proinflammatory cytokines to mediate the pathogenesis of abdominal aortic aneurysm
发表年份:2022 来源杂志:EXPERIMENTAL CELL RESEARCH

51. Sanguinarine Represses the Growth and Metastasis of Non-small Cell Lung Cancer by Facilitating Ferroptosis
发表年份:2022 来源杂志:CURRENT PHARMACEUTICAL DESIGN

52. Tripartite Motif Containing 26 is a Positive Predictor for Endometrial Carcinoma Patients and Regulates Cell Survival in Endometrial Carcinoma
发表年份:2022 来源杂志:HORMONE AND METABOLIC RESEARCH

53. RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA
发表年份:2021 来源杂志:Clinical and Translational Medicine

54. Tumour-Targeted and Redox-Responsive Mesoporous Silica Nanoparticles for Controlled Release of Doxorubicin and an siRNA Against Metastatic Breast Cancer
发表年份:2021 来源杂志:International Journal of Nanomedicine

55. Enzalutamide-Induced Upregulation of PCAT6 Promotes Prostate Cancer Neuroendocrine Differentiation by Regulating miR-326/HNRNPA2B1 Axis
发表年份:2021 来源杂志:Frontiers in Oncology

56. Downregulated F-Box/LRR-Repeat Protein 7 Facilitates Pancreatic Cancer Metastasis by Regulating Snail1 for Proteasomal Degradation
发表年份:2021 来源杂志:Frontiers in Genetics

57. RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination
发表年份:2021 来源杂志:ENVIRONMENTAL TOXICOLOGY

58. Fat1 suppresses the tumor-initiating ability of nonsmall cell lung cancer cells by promoting Yes-associated protein 1 nuclear-cytoplasmic translocation
发表年份:2021 来源杂志:ENVIRONMENTAL TOXICOLOGY

59. Long non‑coding RNA LINC01224 promotes cell proliferation and inhibits apoptosis by regulating AKT3 expression via targeting miR‑485‑5p in endometrial carcinoma
发表年份:2021 来源杂志:ONCOLOGY REPORTS

60. Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
发表年份:2021 来源杂志:IMMUNOLOGICAL INVESTIGATIONS

61. Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR‑145‑5p/TOP2A axis
发表年份:2021 来源杂志:Molecular Medicine Reports

62. Upregulated osteoprotegerin expression promotes lung cancer cell invasion by increasing miR‑20a expression
发表年份:2021 来源杂志:Experimental and Therapeutic Medicine

63. The p53-inducible CLDN7 regulates colorectal tumorigenesis and has prognostic significance
发表年份:2020 来源杂志:NEOPLASIA

64. GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway
发表年份:2019 来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

65. Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities
发表年份:2019 来源杂志:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

66. Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis
发表年份:2019 来源杂志:INTERNATIONAL JOURNAL OF ONCOLOGY

67. The miRNA-149-5p/MyD88 axis is responsible for ursolic acid-mediated attenuation of the stemness and chemoresistance of non-small cell lung cancer cells
发表年份:2019 来源杂志:ENVIRONMENTAL TOXICOLOGY

68. Elevated MIR100HG promotes colorectal cancer metastasis and is associated with poor prognosis
发表年份:2019 来源杂志:Oncology Letters

69. miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer
发表年份:2018 来源杂志:Journal of Molecular Cell Biology

70. Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles
发表年份:2018 来源杂志:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

71. Targeting endogenous DLK1 exerts antitumor effect on hepatocellular carcinoma through initiating cell differentiation
发表年份:2016 来源杂志:Oncotarget

72. Glyoxalase-1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose-Derived Stem Cells in Streptozotocin-Induced Diabetic Mice Model of Critical Limb Ischemia
发表年份:2016 来源杂志:Stem Cells Translational Medicine

73. Disruption and inactivation of the PP2A complex promotes the proliferation and angiogenesis of hemangioma endothelial cells through activating AKT and ERK
发表年份:2015 来源杂志:Oncotarget

展开

你也可能感兴趣

Tamoxifen诱导Cre-ERT2小鼠 使用指南

Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。

查看

【小鼠大学问】基因工程小鼠的命名规则

常见的基因工程小鼠可以分为两种命名方式,包括基因定点修饰的小鼠命名,比如:敲除、敲入、点突变等等,和随机转基因的小鼠命名。

查看

Cre-lox系统介绍及使用汇总

你一定听说过Cre-lox重组系统,无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点,如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统,可以在特定细胞、组织或整个生物体,甚至在特定时间点敲除或表达某个基因,实现对特定基因的时空特异性操作,这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。

查看