历年文献基因敲除小鼠_转基因小鼠定制

                            
                            Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
                        

产品名称：M-NSG

研究领域：肿瘤及肿瘤免疫;急性髓系白血病

发表年份：2024 发表杂志：Nature Communications

                            
                            Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies
                        

产品名称：M-NSG

研究领域：肿瘤及肿瘤免疫;B 细胞恶性肿瘤

发表年份：2024 发表杂志：Nature Communications

                            
                            ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis
                        

产品名称：M-NSG

研究领域：肿瘤及肿瘤免疫;三阴性乳腺癌

发表年份：2024 发表杂志：Journal for ImmunoTherapy of Cancer

                            
                            Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
                        

产品名称：Adrb2-KO

研究领域：神经; 股骨头骨坏死 (ONFH) 、糖皮质激素 (GC)

发表年份：2024 发表杂志：Bone Research

                            
                            Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy
                        

产品名称：Rag1-KO(Rag1-EGFP);M-NSG

研究领域：肿瘤及肿瘤免疫;癌症免疫治疗

发表年份：2024 发表杂志：CANCER CELL

                            
                            Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylation-mediated p38 MAPK phosphorylation
                        

产品名称：Cpt1a-Flox;CAG-GFP-Tg

研究领域：代谢心血管;心脏再生和心肌梗死治疗

发表年份：2024 发表杂志：Acta Pharmaceutica Sinica B

                            
                            NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia
                        

产品名称：R26-CreERT2

研究领域：肿瘤及肿瘤免疫;急性髓系白血病(AML)异常代谢

发表年份：2024 发表杂志：NATURE CELL BIOLOGY

                            
                            Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment
                        

产品名称：hCD3EDG/hPD-L1;huPBMC-M-NSG

研究领域：肿瘤及肿瘤免疫;癌症治疗

发表年份：2024 发表杂志：CELL

                            
                            PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway
                        

产品名称：Pink1-Flox

研究领域：自身免疫及炎症;心脏肥大、心衰炎症

发表年份：2024 发表杂志：CARDIOVASCULAR RESEARCH

                            
                            Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in hepatocellular carcinoma
                        

产品名称：H11-CAG-LSL-Myc

研究领域：肿瘤及肿瘤免疫;肝细胞癌

发表年份：2024 发表杂志：Cellular & Molecular Immunology

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Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation

Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies

ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis

Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head

Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy

Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylation-mediated p38 MAPK phosphorylation

NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia

Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment

PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway

Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in hepatocellular carcinoma

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