历年文献基因敲除小鼠_转基因小鼠定制

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

产品名称：M-NSG

研究领域：代谢; 线粒体自噬

发表年份：2025 发表杂志：NATURE

                            
                            Inhibiting Liver-Derived C3 Protein Rescues Anesthesia/Surgery-Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis
                        

产品名称：C57BL/6

研究领域：神经;术后认知功能障碍

发表年份：2025 发表杂志：Advanced Science

                            
                            Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status
                        

产品名称：Kras-LSL-G12C

研究领域：非小细胞肺癌; 靶向治疗耐药性

发表年份：2025 发表杂志：Nature Communications

                            
                            High-Resolution Multiplexed Sequencing of Single-Cell Full-length Transcriptome Via Combinational Barcoded Tn5 Transposon Insertion
                        

产品名称：C57BL/6

研究领域：单细胞RNA测序技术; Tn5转座子

发表年份：2025 发表杂志：Advanced Science

                            
                            HIF-1α in CD4+ T cells drives gout pathogenesis via metabolic reprogramming and Th17 differentiation
                        

产品名称：Uox-KO;CD4-Cre

研究领域：代谢重编程; 痛风

发表年份：2025 发表杂志：Journal of Pharmaceutical Analysis

                            
                            GDF15 induces excessive activation of osteoclasts within the vertebral endplates leading to early endplate degeneration
                        

产品名称：Gdf15-Flox

研究领域：骨代谢; 脊柱退行性疾病

发表年份：2025 发表杂志：JCI Insight

                            
                            Piezo1 Upregulation in Monocyte-Derived Macrophages Impairs Post-Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis
                        

产品名称：Lyz2-Cre

研究领域：心肌梗死; 巨噬细胞

发表年份：2025 发表杂志：Advanced Science

                            
                            Loss of Slc39a5 in α-cells impairs glucose metabolism by chronically increasing glucagon
                        

产品名称：Slc39a5-Flox

研究领域：葡萄糖代谢; 2型糖尿病

发表年份：2025 发表杂志：Journal of Advanced Research

                            
                            E3 ligase CHIP restoration facilitates the effect of α1-adrenoceptor blockage on alleviating lipopolysaccharide-caused cardiac fibrosis via downregulating TGF-BR1 expression and Smad2/3 activation
                        

产品名称：Chip-KO

研究领域：败血症; 心肌纤维化

发表年份：2025 发表杂志：Molecular Biomedicine

                            
                            Genetic variants in HELB contribute to premature ovarian insufficiency and early age of natural menopause
                        

产品名称：Helb-D112Y

研究领域：早发性卵巢功能不全

发表年份：2025 发表杂志：JCI Insight

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Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

Inhibiting Liver-Derived C3 Protein Rescues Anesthesia/Surgery-Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status

High-Resolution Multiplexed Sequencing of Single-Cell Full-length Transcriptome Via Combinational Barcoded Tn5 Transposon Insertion

HIF-1α in CD4+ T cells drives gout pathogenesis via metabolic reprogramming and Th17 differentiation

GDF15 induces excessive activation of osteoclasts within the vertebral endplates leading to early endplate degeneration

Piezo1 Upregulation in Monocyte-Derived Macrophages Impairs Post-Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis

Loss of Slc39a5 in α-cells impairs glucose metabolism by chronically increasing glucagon

E3 ligase CHIP restoration facilitates the effect of α1-adrenoceptor blockage on alleviating lipopolysaccharide-caused cardiac fibrosis via downregulating TGF-BR1 expression and Smad2/3 activation

Genetic variants in HELB contribute to premature ovarian insufficiency and early age of natural menopause

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