历年文献基因敲除小鼠_转基因小鼠定制

                            
                            Inhibiting the P2X7R-NLRP3 inflammasome pathway regulates CXCL16 to alleviate podocyte injury in mice with adriamycin nephropathy
                        

产品名称：Nlrp3-KO

研究领域：原发性肾病综合征;肾小球硬化;足细胞损伤

发表年份：2026 发表杂志：Scientific Reports

                            
                            Pedunculoside ameliorates liver fibrosis by targeting c-Jun to inhibit hepatic stellate cell activation
                        

产品名称：C57BL/6

研究领域：肝纤维化

发表年份：2026 发表杂志：INTERNATIONAL IMMUNOPHARMACOLOGY

                            
                            Leptomeningeal metastatic cancer cells induce a permissive choroid plexus vasculature through extracellular-vesicle-derived 5-HIAA signaling
                        

产品名称：Cdh5-2A-CreERT2;Ahr-Flox

研究领域：软脑膜转移性癌;脉络丛血管;代谢微环境

发表年份：2026 发表杂志：Nature Cancer

                            
                            Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine–ZBTB5–mTORC1 axis
                        

产品名称：Anxa10-2A-CreERT2;Trp53-Flox/Kras-LSL-G12D;Cd8a-IRES-DTRGFP;Rag1-KO

研究领域：肿瘤微环境;肿瘤免疫

发表年份：2026 发表杂志：NATURE CELL BIOLOGY

                            
                            LincRNA-EPS alleviates osteoclastogenesis under inflammatory microenvironment through preventing excessive iron metabolism
                        

产品名称：LincRNA-EPS-KO

研究领域：铁代谢;破骨细胞;牙周炎

发表年份：2026 发表杂志：Cell Death & Disease

                            
                            TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, leading to anxiety-like behaviors
                        

产品名称：Trem2-KO

研究领域：焦虑;神经

发表年份：2026 发表杂志：JOURNAL OF ALZHEIMERS DISEASE

                            
                            A unique CD4⁺ T cell subset expressing granzyme K is regulated by transcription factor EOMES and important for T cell-mediated intestinal inflammation
                        

产品名称：Gzmk-2A-CreERT2-2A-tdTomato

研究领域：CD4+ T细胞;肠道炎症

发表年份：2026 发表杂志：NATURE IMMUNOLOGY

                            
                            Acute stress alleviates type 2 lung inflammation by restricting ILC2s through corticosterone-glucocorticoid receptor signaling
                        

产品名称：Nr3c1-Flox

研究领域：急性短期压力;炎症

发表年份：2026 发表杂志：Cellular & Molecular Immunology

                            
                            Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury
                        

产品名称：Cx3cr1-CreERT2

研究领域：创伤性脑损伤;衰老

发表年份：2026 发表杂志：JOURNAL OF CLINICAL INVESTIGATION

                            
                            Interleukin-27 remodels the bone marrow niche to suppress B-cell development and leukaemia progression in mouse models
                        

产品名称：Cd45.1;Il27ra-Flox;M-NSG

研究领域：B细胞发育;白血病

发表年份：2026 发表杂志：EBioMedicine

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Inhibiting the P2X7R-NLRP3 inflammasome pathway regulates CXCL16 to alleviate podocyte injury in mice with adriamycin nephropathy

Pedunculoside ameliorates liver fibrosis by targeting c-Jun to inhibit hepatic stellate cell activation

Leptomeningeal metastatic cancer cells induce a permissive choroid plexus vasculature through extracellular-vesicle-derived 5-HIAA signaling

Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine–ZBTB5–mTORC1 axis

LincRNA-EPS alleviates osteoclastogenesis under inflammatory microenvironment through preventing excessive iron metabolism

TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, leading to anxiety-like behaviors

A unique CD4⁺ T cell subset expressing granzyme K is regulated by transcription factor EOMES and important for T cell-mediated intestinal inflammation

Acute stress alleviates type 2 lung inflammation by restricting ILC2s through corticosterone-glucocorticoid receptor signaling

Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury

Interleukin-27 remodels the bone marrow niche to suppress B-cell development and leukaemia progression in mouse models

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