Pln-2A-CreERT2
品系全名
C57BL/6Smoc-Plnem1(2A-CreERT2)Smoc
目录号
NM-KI-242510
品系状态
精子冻存
基因信息
基因名
Pln
品系描述
验证数据
Fig1. CreERT2 mediated recombination in heart of PlnCreERT2/+; Rosa26tdTomato/+ mouse.
Fig2. CreERT2 mediated recombination in heart of PlnCreERT2/+; Rosa26tdTomato/+ mouse.
Fig3. Detection of tdTomato(red) in various tissues of PlnCreERT2/+; Rosa26tdTomato/+ mouse.
In female mice, tissues with tdTomato expression after tamoxifen induction include: brain, kidney, heart, reproductive system, muscle, pancreas, and vagina. Mouse age: 64 days, female.
In male mice, tissues with tdTomato expression after tamoxifen induction: brain, kidney, heart, reproductive system, muscle, pancreas, prostate. Mouse age: 28 days, male. (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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