NOD SCID

品系全名

NOD.Cg-Prkdcscid/NifdcSmoc

目录号

SM-019

品系状态

活体

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品系描述

该品系为非肥胖糖尿病（NOD）小鼠背景携带Scid自发突变，NOD SCID小鼠不会发生糖尿病，缺乏T细胞和B细胞，同时具备固有免疫缺陷。NOD SCID小鼠适合移植的细胞系种类较裸鼠更多；适用于部分PDX模型的移植；自发胸腺淋巴瘤，寿命短（约为6-9个月），不适合长期实验。

验证数据

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Fig1. Body weight growth curve of NOD SCID (n=1046)

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Fig 2. Detection of serum antibody subclasses in NOD SCID mice (8-week old, male).

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Fig3. Complete deletion of T, B and NK cells of NOD SCID mice. Spleen and peripheral blood cells NOD SCID mice were collected to analyze their compositions of T, B and NK cells by FACS.

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Fig4. Complete deletion of Monocytes, macrophages and DC cells of NOD SCID mice. Spleen and peripheral blood cells NOD SCID mice were collected to analyze their compositions of Monocytes, macrophages and DC cells by FACS.

image.pngFig5. Pathological examination of various tissues in NOD SCID mice. Thymus was absent in NOD SCID mice, and no significant pathologic abnormalities were found in the other tissues examined (8-week old, A males, B females).

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Fig6. Subcutaneous xenograft tumor growth in NOD SCID. 

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Fig7. Blood routine tests in NOD SCID.

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Fig8. Blood biochemistry in NOD SCID.

Table 1. NOD SCID xenograft cell lines

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发表文献 18篇

1. An mRNA-encoded scFv antibody targeting the helix-α3 of HPV18 E7 oncoprotein as a novel antiviral strategy
发表年份：2026 来源杂志：mBio

2. Large-scale manufacturing of human gallbladder epithelial cell products and derived hepatocytes via a chemically defined approach
发表年份：2025 来源杂志：TRENDS IN BIOTECHNOLOGY

3. Trifluridine/Tipiracil Exhibits Potent Antitumor Activity in Triple-Negative Breast Cancer by Targeting SKP2 and Inducing Cell Cycle Arrest and Apoptosis
发表年份：2025 来源杂志：Current Pharmaceutical Analysis

4. Necroptosis enhances ‘don’t eat me’ signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis
发表年份：2024 来源杂志：Nature Communications

5. Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple-Negative Breast Cancer Progression via Epigenetic Modulation of SREBP1-Regulated Cholesterol Metabolism
发表年份：2024 来源杂志：Advanced Science

6. CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway
发表年份：2023 来源杂志：Cancer Communications

7. Fatty acids support the fitness and functionality of tumor resident CD8+ T cells by maintaining SCML4 expression
发表年份：2023 来源杂志：CANCER RESEARCH

8. Inhibition of Mitochondrial Biosynthesis Using a “Right-Side-Out” Membrane-Camouflaged Micelle to Facilitate the Therapeutic Effects of Shikonin on Triple-Negative Breast Cancer
发表年份：2022 来源杂志：Advanced Healthcare Materials

9. Induced expression of CCL19 promotes the anti-tumor ability of CAR-T cells by increasing their infiltration ability
发表年份：2022 来源杂志：Frontiers in Immunology

10. Daratumumab Prevents Experimental Xenogeneic Graft-Versus-Host Disease by Skewing Proportions of T Cell Functional Subsets and Inhibiting T Cell Activation and Migration
发表年份：2021 来源杂志：Frontiers in Immunology

11. LncRNA PCIR Is an Oncogenic Driver via Strengthen the Binding of TAB3 and PABPC4 in Triple Negative Breast Cancer
发表年份：2021 来源杂志：Frontiers in Oncology

12. Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition
发表年份：2020 来源杂志：Frontiers in Cell and Developmental Biology

13. 4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2nd Generation Chimeric Antigen Receptor-Modified T Cells
发表年份：2020 来源杂志：Frontiers in Immunology

14. Long noncoding RNA LINC00467 facilitates the progression of acute myeloid leukemia by targeting the miR-339/SKI pathway
发表年份：2020 来源杂志：LEUKEMIA & LYMPHOMA

15. Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy
发表年份：2019 来源杂志：Nature Communications

16. VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
发表年份：2017 来源杂志：Nature Communications

17. Cuprous oxide nanoparticle-inhibited melanoma progress by targeting melanoma stem cells
发表年份：2017 来源杂志：International Journal of Nanomedicine

18. Altered Hepa1-6 cells by dimethyl sulfoxide (DMSO)-treatment induce anti-tumor immunity in vivo
发表年份：2016 来源杂志：Oncotarget

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