BALB/c

品系全名

BALB/cAnSmoc

目录号

SM-003

品系状态

活体

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品系描述

BALB/c小鼠毛色白化，是生物医学研究中使用最广泛的近交系模型之一，特别是在免疫学和传染病研究中应用广泛。乳腺肿瘤发生率约为10%~20%。有一定数量的卵巢、肾上腺和肺部肿瘤、白血病的发生。肺癌发病率雌性26%，雄性29%。白血病发病率雌性12%，雄性10%。血压与其他近交系小鼠相比为最高，有自发高血压症。

验证数据


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图1. BALB/c小鼠血常规检测。


发表文献 28篇

1. Celastrol induces ferroptosis in ccRCC through TEF-Driven ACOX2 upregulation and metabolic reprogramming
发表年份：2026 来源杂志：PHYTOMEDICINE

2. Early growth response 2 activates MAF bZIP transcription factor F to protect β-cells from oxidative stress in type 1 diabetes
发表年份：2025 来源杂志：TISSUE & CELL

3. Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
发表年份：2024 来源杂志：Bioactive Materials

4. NIR-II light-activated and Cu nanocatalyst-enabled bioorthogonal reaction in living systems for efficient tumor therapy
发表年份：2024 来源杂志：Nano Today

5. Protection against DSS-induced colitis in mice through FcεRIα deficiency: the role of altered Lactobacillus
发表年份：2024 来源杂志：npj Biofilms and Microbiomes

6. Engineered Probiotic-mediated Intratumoral Delivery and Controlled Release of Bacterial Collagenase for Cancer Therapy
发表年份：2024 来源杂志：Synthetic and Systems Biotechnology

7. Simple ROS-responsive micelles loaded Shikonin for efficient ovarian cancer targeting therapy by disrupting intracellular redox homeostasis
发表年份：2024 来源杂志：EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

8. Jiedu recipe, a compound Chinese herbal medicine, suppresses hepatocellular carcinoma metastasis by inhibiting the release of tumor-derived exosomes in a hypoxic microenvironment
发表年份：2024 来源杂志：Journal of Integrative Medicine-JIM

9. Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
发表年份：2022 来源杂志：JCI Insight

10. Resveratrol Attenuates Ankylosing Spondylitis in Mice by Inhibiting the TLR4/NF-κB/NLRP3 Pathway and Regulating Gut Microbiota
发表年份：2022 来源杂志：IMMUNOLOGICAL INVESTIGATIONS

11. Nootkatone Improves Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors by Repressing NF-κB/NLRP3-Mediated Neuroinflammation
发表年份：2022 来源杂志：Chinese Journal of Integrative Medicine

12. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells
发表年份：2021 来源杂志：MOLECULAR CELL

13. Biomimetic cytomembrane nanovaccines prevent breast cancer development in the long term
发表年份：2021 来源杂志：Nanoscale

14. Ablation of Survivin in T Cells Attenuates Acute Allograft Rejection after Murine Heterotopic Heart Transplantation by Inducing Apoptosis
发表年份：2021 来源杂志：Frontiers in Immunology

15. Enzyme-linked immunosorbent assays for quantification of MMAE-conjugated ADCs and total antibodies in cynomolgus monkey sera
发表年份：2021 来源杂志：Journal of Pharmaceutical Analysis

16. lncRNA OIP5-AS1 Suppresses Cell Proliferation and Invasion of Endometrial Cancer by Regulating PTEN/AKT via Sponging miR-200c-3p
发表年份：2021 来源杂志：Journal of Immunology Research

17. Hsa_circ_0004712 downregulation attenuates ovarian cancer malignant development by targeting the miR-331-3p/FZD4 pathway
发表年份：2021 来源杂志：Journal of Ovarian Research

18. Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
发表年份：2021 来源杂志：IMMUNOLOGICAL INVESTIGATIONS

19. Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro
发表年份：2021 来源杂志：JOURNAL OF APPLIED TOXICOLOGY

20. Transcriptional profiling and network pharmacology analysis identify the potential biomarkers from Chinese herbal formula Huosu Yangwei Formula treated gastric cancer in vivo
发表年份：2021 来源杂志：Chinese Journal of Natural Medicines

21. LINC00261 relieves the progression of sepsis-induced acute kidney injury by inhibiting NF-κB activation through targeting the miR-654-5p/SOCS3 axis
发表年份：2021 来源杂志：JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

22. Six1 Promotes Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells via the TGFβ1/Smad Signalling Pathway
发表年份：2021 来源杂志：INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

23. Assembly of two mixed-ligand Co(II) complexes: crystal structures and protective activity on acute myocardial infarction
发表年份：2021 来源杂志：Journal of the Iranian Chemical Society

24. Extracellular vesicles engineered with valency-controlled DNA nanostructures deliver CRISPR/Cas9 system for gene therapy
发表年份：2020 来源杂志：NUCLEIC ACIDS RESEARCH

25. Autophagy-lysosome inhibitor chloroquine prevents CTLA-4 degradation of T cells and attenuates acute rejection in murine skin and heart transplantation
发表年份：2020 来源杂志：Theranostics

26. Longevity Effect of Liuwei Dihuang in Both Caenorhabditis Elegans and Aged Mice
发表年份：2019 来源杂志：Aging and Disease

27. Downregulation of homeobox gene Barx2 increases gastric cancer proliferation and metastasis and predicts poor patient outcomes
发表年份：2016 来源杂志：Oncotarget

28. MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression
发表年份：2016 来源杂志：Oncotarget

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