Rag2-KO

品系全名

C57BL/6JSmo-Rag2em2Smoc

目录号

NM-KO-190429

品系状态

活体

导出PDF

基因信息

基因名
Rag2

基因曾用名

Rag-2

NCBI ID

19374 

MGI ID

97849

Ensembl ID

ENSMUSG00000032864

Pubmed

Rag2

人类同源基因

RAG2

品系描述

敲除Rag2基因exon 3部分编码序列，从而造成移码功能缺失，建立Rag2基因敲除小鼠模型。
应用领域：免疫缺陷，荷瘤模型

疾病预测

溃疡性结肠炎
Ulcerative Colitis

近似模型的表型

MGI:4360989
注：该品系需与Tbx21-KO(NM-KO-190157)交配才可能获得预期表型

参考文献

Garrett WS, Lord GM, Punit S, Lugo-Villarino G, Mazmanian SK, Ito S, Glickman JN, Glimcher LH, Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007 Oct 5;131(1):33-45

重度联合免疫缺陷，常染色体隐性遗传，T细胞阴性，B细胞阴性，Nk细胞阳性
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive

近似模型的表型

MGI:2174910

参考文献

Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendelsohn M, Charron J, Datta M, Young F, Stall AM, Alt FW, RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 1992 Mar 6;68(5):855-67

验证数据

T、B细胞FACS检测.png

图1. Rag2(-/-)小鼠脾脏和外周血中的T 、B细胞缺失。

取Rag2(-/-)小鼠的外周血和脾脏细胞，并通过FACS对其中T 、B细胞的组成进行分析。

发表文献 11篇

1. Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
发表年份：2024 来源杂志：Cell Metabolism

2. Midline-1 regulates effector T cell motility in experimental autoimmune encephalomyelitis via mTOR/microtubule pathway
发表年份：2024 来源杂志：Theranostics

3. Pseudokinase STK40 promotes TH1 and TH17 cell differentiation by targeting FOXO transcription factors
发表年份：2024 来源杂志：Science Advances

4. LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway
发表年份：2024 来源杂志：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

5. Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy
发表年份：2023 来源杂志：CANCER RESEARCH

6. Androgens drive sexual dimorphism in liver metastasis by promoting hepatic accumulation of neutrophils
发表年份：2022 来源杂志：Cell Reports

7. Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis
发表年份：2021 来源杂志：International Journal of Biological Sciences

8. Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
发表年份：2021 来源杂志：iScience

9. E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases
发表年份：2020-07-01 来源杂志：The Journal of Clinical Investigation

10. E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases
发表年份：2020 来源杂志：JOURNAL OF CLINICAL INVESTIGATION

11. MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation
发表年份：2018 来源杂志：JOURNAL OF CLINICAL INVESTIGATION

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