hTDP43-A315T
品系全名
C57BL/6Smoc-Tgtn(pPrp-hTDP-43 A315T)1Smoc
目录号
NM-KI-234659
品系状态
活体
品系描述
将pPrp-hTDP-43 A315T插入到小鼠Chr9处。
验证数据
Fig.1 TDP43 mRNA sequencing in hTDP43-A315T mice. Sequencing data of RT-PCR products confirmed the presence of the target mutation in hTDP43-A315T mice. (Female, 3 weeks old)
Abbr. HE, heterozygous; WT, wild type.
Fig.2 Detection of human TDP43 expression in hTDP43-A315T mice by WB. Tissues lysates were collected from spinal cord and brain of wild-type C57BL/6 mice (female, 3 weeks old) and heterozygous hTDP43-A315T mice (female, 3 weeks old), and then analyzed by western blot with anti-TDP43 antibody (abnova, H00023435-M01). 20 μg of total proteins were loaded for western blotting analysis.
Abbr. M,marker; HE, heterozygous; WT, wild type.
你也可能感兴趣
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
查看
