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Shanghai Model Organisms Zebrafish Technical Service Platform
The platform has been certified by AAALAC international authority, and can accommodate nearly 5,000 adult zebrafish and more than 20,000 embryos per week; it has successfully applied for many government research projects and cooperated with more than 30 units in zebrafish technology. The services include:
Gene editing and function research
Rapid pharmacodynamics evaluation and screening
Drug safety assessment
Shanghai Model Organisms Nematod Technical Service Platform
can provided a variety of nematode related experimental services, including:
Nematod gene editing (gene modification, gene knock-out, RNAi)
Study on aging and lifespan
Oxidative stress research
Pharmacodynamics evaluation
Water and soil environmental assessment
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Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
查看你一定听说过Cre-lox重组系统，无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点，如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统，可以在特定细胞、组织或整个生物体，甚至在特定时间点敲除或表达某个基因，实现对特定基因的时空特异性操作，这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。
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