hPD-L1(2)

品系全名

C57BL/6Smoc-Cd274em2(hPD-L1)Smoc

目录号

NM-HU-190039

品系状态

胚胎冻存

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基因信息

基因名
Cd274

品系描述

通过同源重组,将小鼠基因Cd274进行人源化修饰。与此相似的品系还有hPD-L1(NM-HU-00062),详细信息请咨询技术顾问。
应用领域:肿瘤研究;免疫治疗;药物筛选;

验证数据

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Fig1. The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis. 

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Fig2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice. 

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Fig3. Immunotype in blood in hPD-L1 mice. 

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Fig4. Immunotype in spleen in hPD-L1 mice. 

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Fig5. Immunotype in bone marrow in hPD-L1 mice. 

PD-L1-HU-2.png

PD-L1-HU-3.png

Fig6.  In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)(A)  PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1. (B) Mean body weight of mice.  All quantitative data are represented as mean ± SEM.


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