历年文献基因敲除小鼠_转基因小鼠定制

                            
                            In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation
                        

产品名称：Dppa3-IRES-Cre

研究领域：其它;肝细胞

发表年份：2023 发表杂志：GENOME BIOLOGY

                            
                            Deficiency in SLC25A15, a hypoxia-responsive gene, promotes hepatocellular carcinoma by reprogramming glutamine metabolism
                        

产品名称：Alb-Cre-Tg/H11-CAG-LSL-Myc

研究领域：肿瘤及肿瘤免疫;肝细胞癌(HCC)

发表年份：2023 发表杂志：JOURNAL OF HEPATOLOGY

                            
                            A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer
                        

产品名称：CDX/PDX模型

研究领域：自身免疫及炎症;TNKS-USP25 PPI

发表年份：2023 发表杂志：Acta Pharmaceutica Sinica B

                            
                            Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts
                        

产品名称：Cdh5-2A-CreERT2

研究领域：代谢心血管;高血压

发表年份：2023 发表杂志：Redox Biology

                            
                            The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells
                        

产品名称：Zeb1-Flox

研究领域：自身免疫及炎症;1型常规树突状细胞(cDC1)

发表年份：2023 发表杂志：Nature Communications

                            
                            CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway
                        

产品名称：NOD SCID

研究领域：肿瘤及肿瘤免疫;乳腺恶性叶状瘤(PTs)

发表年份：2023 发表杂志：Cancer Communications

                            
                            KDM6A promotes hepatocellular carcinoma progression and dictates lenvatinib efficacy by upregulating FGFR4 expression
                        

产品名称：Kdm6a-Flox

研究领域：肿瘤及肿瘤免疫;肝细胞癌(HCC)

发表年份：2023 发表杂志：Clinical and Translational Medicine

                            
                            SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling.
                        

产品名称：Rbpj-Flox

研究领域：肿瘤及肿瘤免疫;肝癌

发表年份：2023 发表杂志：JOURNAL OF CLINICAL INVESTIGATION

                            
                            Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy
                        

产品名称：Rag2-KO;Igsf9-Flox;M-NSG

研究领域：自身免疫及炎症;IGSF9

发表年份：2023 发表杂志：CANCER RESEARCH

                            
                            The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity
                        

产品名称：Clec4n-KO

研究领域：自身免疫及炎症;ermap -半凝集素-9-探测素-2轴

发表年份：2023 发表杂志：NATURE IMMUNOLOGY

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In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

Deficiency in SLC25A15, a hypoxia-responsive gene, promotes hepatocellular carcinoma by reprogramming glutamine metabolism

A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer

Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts

The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells

CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway

KDM6A promotes hepatocellular carcinoma progression and dictates lenvatinib efficacy by upregulating FGFR4 expression

SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling.

Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy

The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity

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