历年文献基因敲除小鼠_转基因小鼠定制

The WFS1-ZnT3-Zn2+ Axis Regulates the Vicious Cycle of Obesity and Depression

产品名称：Wfs1-Flox

研究领域：代谢心血管;肥胖与抑郁症之间关联

发表年份：2024 发表杂志：Advanced Science

                            
                            A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner
                        

产品名称：Ltb4r1-KO

研究领域：代谢心血管;特定的脂质代谢增强抗原特异性粘膜IgA

发表年份：2024 发表杂志：Nature Communications

Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity

产品名称：Zdhhc24-KO

研究领域：自身免疫及炎症;先天免疫

发表年份：2024 发表杂志：MOLECULAR CELL

                            
                            Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies
                        

产品名称：M-NSG

研究领域：肿瘤及肿瘤免疫;白血病

发表年份：2024 发表杂志：Journal of Advanced Research

                            
                            A CD25×TIGIT bispecific antibody induces anti-tumor activity through selective intratumoral Treg cell depletion
                        

产品名称：hIL2RA

研究领域：肿瘤及肿瘤免疫;瘤内调节性 T 细胞 (Treg)

发表年份：2024 发表杂志：MOLECULAR THERAPY

                            
                            YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment
                        

产品名称：Ythdf2-Flox

研究领域：肿瘤及肿瘤免疫;瘤周肝细胞

发表年份：2024 发表杂志：Molecular Cancer

                            
                            RGS5+ lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism
                        

产品名称：Rgs5-KO

研究领域：肿瘤及肿瘤免疫;乳腺癌

发表年份：2024 发表杂志：DRUG RESISTANCE UPDATES

                            
                            Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases
                        

产品名称：Clu-Flox

研究领域：神经;多发性硬化症

发表年份：2024 发表杂志：Nature Communications

                            
                            Unraveling the spatial organization and development of human thymocytes through integration of spatial transcriptomics and single-cell multi-omics profiling
                        

产品名称：R26-CAG-Cas9

研究领域：自身免疫及炎症;人类胸腺细胞

发表年份：2024 发表杂志：Nature Communications

                            
                            Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis
                        

产品名称：Cdkn2a-Luc-2A-tdTomato-2A-CreERT2

研究领域：代谢心血管;细胞凋亡

发表年份：2024 发表杂志：JOURNAL OF NANOBIOTECHNOLOGY

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The WFS1-ZnT3-Zn2+ Axis Regulates the Vicious Cycle of Obesity and Depression

A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner

Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity

Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies

A CD25×TIGIT bispecific antibody induces anti-tumor activity through selective intratumoral Treg cell depletion

YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment

RGS5+ lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism

Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases

Unraveling the spatial organization and development of human thymocytes through integration of spatial transcriptomics and single-cell multi-omics profiling

Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis

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