Vhl-Flox

品系全名

C57BL/6Smoc-Vhlem1(flox)Smoc

目录号

NM-CKO-200016

品系状态

活体

导出PDF

基因信息

基因名
Vhl

基因曾用名

Vhlh， pVHL

NCBI ID

22346

MGI ID

103223

Ensembl ID

ENSMUSG00000033933

Pubmed

Vhl

人类同源基因

VHL

人类同源基因关联疾病 

Von Hippel-Lindau综合症、肾肿瘤、红细胞增多症

品系描述

在Vhl基因exon 2-3两侧分别插入loxP位点，该flox小鼠可与组织特异性Cre工具鼠交配，获得在特定细胞类型或组织中敲除Vhl基因的小鼠模型。
应用领域：肿瘤相关研究

疾病预测

婴儿猝死综合症
sudden infant death syndrome

近似模型的表型

MGI:5304714
注：该品系与Myh6-cre工具鼠交配才可能获得预期表型

参考文献

Neary MT, Mohun TJ, Breckenridge RA, A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndrome. Dis Model Mech. 2012 Nov 16;6(2):503-7

von Hippel-Lindau病
von Hippel-Lindau disease

近似模型的表型

MGI:2677759
注：该品系与ACTB-cre工具鼠交配才可能获得预期表型

参考文献

Ma W, Tessarollo L, Hong SB, Baba M, Southon E, Back TC, Spence S, Lobe CG, Sharma N, Maher GW, Pack S, Vortmeyer AO, Guo C, Zbar B, Schmidt LS, Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res. 2003 Sep 1;63(17):5320-8

von Hippel-Lindau病
von Hippel-Lindau disease

近似模型的表型

MGI:3621460
注：该品系与Pck1-cre工具鼠交配才可能获得预期表型

参考文献

Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH, Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol. 2005 Apr;25(8):3163-72

von Hippel-Lindau病
von Hippel-Lindau disease

近似模型的表型

MGI:3621461
注：该品系与Hif1a-Flox(NM-CKO-190065)和Pck1-cre工具鼠交配才可能获得预期表型

参考文献

Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH, Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol. 2005 Apr;25(8):3163-72

von Hippel-Lindau病
von Hippel-Lindau disease

近似模型的表型

MGI:3844061
注：该品系与Gcg-cre工具鼠交配才可能获得预期表型

参考文献

Shen HC, Adem A, Ylaya K, Wilson A, He M, Lorang D, Hewitt SM, Pechhold K, Harlan DM, Lubensky IA, Schmidt LS, Linehan WM, Libutti SK, Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. PLoS One. 2009;4(4):e4897

婴儿猝死综合症
Sudden Infant Death Syndrome

近似模型的表型

MGI:5304714
注：该品系与Myh6-cre工具鼠交配才可能获得预期表型

参考文献

Neary MT, Mohun TJ, Breckenridge RA, A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndrome. Dis Model Mech. 2012 Nov 16;6(2):503-7

von Hippel-Lindau病
Von Hippel-Lindau Disease

近似模型的表型

MGI:2677759
注：该品系与ACTB-cre工具鼠交配才可能获得预期表型

参考文献

Ma W, Tessarollo L, Hong SB, Baba M, Southon E, Back TC, Spence S, Lobe CG, Sharma N, Maher GW, Pack S, Vortmeyer AO, Guo C, Zbar B, Schmidt LS, Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res. 2003 Sep 1;63(17):5320-8

von Hippel-Lindau病
Von Hippel-Lindau Disease

近似模型的表型

MGI:3621460
注：该品系与Pck1-cre工具鼠交配才可能获得预期表型

参考文献

Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH, Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol. 2005 Apr;25(8):3163-72

von Hippel-Lindau病
Von Hippel-Lindau Disease

近似模型的表型

MGI:3621461
注：该品系与Hif1a-Flox(NM-CKO-190065)和Pck1-cre工具鼠交配才可能获得预期表型

参考文献

Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH, Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol. 2005 Apr;25(8):3163-72

von Hippel-Lindau病
Von Hippel-Lindau Disease

近似模型的表型

MGI:3844061
注：该品系与Gcg-cre工具鼠交配才可能获得预期表型

参考文献

Shen HC, Adem A, Ylaya K, Wilson A, He M, Lorang D, Hewitt SM, Pechhold K, Harlan DM, Lubensky IA, Schmidt LS, Linehan WM, Libutti SK, Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. PLoS One. 2009;4(4):e4897

von Hippel-Lindau病
Von Hippel-Lindau Disease

近似模型的表型

MGI:3844062
注：该品系与Ins2-cre工具鼠交配才可能获得预期表型

参考文献

Shen HC, Adem A, Ylaya K, Wilson A, He M, Lorang D, Hewitt SM, Pechhold K, Harlan DM, Lubensky IA, Schmidt LS, Linehan WM, Libutti SK, Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. PLoS One. 2009;4(4):e4897

von Hippel-Lindau病
Von Hippel-Lindau Disease

近似模型的表型

MGI:3844065
注：该品系与Pdx1-cre工具鼠交配才可能获得预期表型

参考文献

Shen HC, Adem A, Ylaya K, Wilson A, He M, Lorang D, Hewitt SM, Pechhold K, Harlan DM, Lubensky IA, Schmidt LS, Linehan WM, Libutti SK, Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. PLoS One. 2009;4(4):e4897

von Hippel-Lindau病
Von Hippel-Lindau Disease

近似模型的表型

MGI:4839497
注：该品系与Pten-Flox(NM-CKO-18004)和Cdh16-cre工具鼠交配才可能获得预期表型

参考文献

Frew IJ, Minola A, Georgiev S, Hitz M, Moch H, Richard S, Vortmeyer AO, Krek W, Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. Mol Cell Biol. 2008 Jul;28(14):4536-48

von Hippel-Lindau病
Von Hippel-Lindau Disease

近似模型的表型

MGI:4943534
注：该品系与Pten-Flox(NM-CKO-18004)和Cdh16-cre工具鼠交配才可能获得预期表型

参考文献

Frew IJ, Thoma CR, Georgiev S, Minola A, Hitz M, Montani M, Moch H, Krek W, pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation. EMBO J. 2008 Jun 18;27(12):1747-57

你也可能感兴趣

Tamoxifen诱导Cre-ERT2小鼠 使用指南

Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。

查看
【小鼠大学问】基因工程小鼠的命名规则

常见的基因工程小鼠可以分为两种命名方式，包括基因定点修饰的小鼠命名，比如：敲除、敲入、点突变等等，和随机转基因的小鼠命名。

查看