Pten-Flox

MGI:3714016
注：该品系与Gfap-cre工具鼠交配才可能获得预期表型

Backman SA, Stambolic V, Suzuki A, Haight J, Elia A, Pretorius J, Tsao MS, Shannon P, Bolon B, Ivy GO, Mak TW, Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet. 2001 Dec;29(4):396-403

MGI:3813525
注：该品系与KRT14-cre工具鼠交配才可能获得预期表型

Squarize CH, Castilho RM, Gutkind JS, Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin. Cancer Res. 2008 Sep 1;68(17):7066-72

MGI:4829793
注：该品系与MMTV-cre工具鼠交配才可能获得预期表型

Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H, Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development. 2002 Sep;129(17):4159-70

MGI:4836620
注：该品系与Mx1-cre工具鼠交配才可能获得预期表型

He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L, PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet. 2007 Feb;39(2):189-98

MGI:5506904
注：该品系与KRT14-cre工具鼠交配才可能获得预期表型

Wang Q, Von T, Bronson R, Ruan M, Mu W, Huang A, Maira SM, Zhao JJ, Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome. Genes Dev. 2013 Jul 15;27(14):1568-80

MGI:5825461
注：该品系与Nes-cre/ERT2工具鼠交配才可能获得预期表型

Zhu G, Rankin SL, Larson JD, Zhu X, Chow LM, Qu C, Zhang J, Ellison DW, Baker SJ, PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation. Cancer Res. 2017 Jan 01;77(1):123-133

MGI:4839497
注：该品系与Vhl-Flox(2)(NM-CKO-200232)和Cdh16-cre工具鼠交配才可能获得预期表型

Frew IJ, Minola A, Georgiev S, Hitz M, Moch H, Richard S, Vortmeyer AO, Krek W, Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. Mol Cell Biol. 2008 Jul;28(14):4536-48

MGI:4943534
注：该品系与Vhl-Flox(2)(NM-CKO-200232)和Cdh16-cre工具鼠交配才可能获得预期表型

Frew IJ, Thoma CR, Georgiev S, Minola A, Hitz M, Montani M, Moch H, Krek W, pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation. EMBO J. 2008 Jun 18;27(12):1747-57

MGI:5004866
注：该品系与Fabp1-cre工具鼠交配才可能获得预期表型

Tsuruta H, Kishimoto H, Sasaki T, Horie Y, Natsui M, Shibata Y, Hamada K, Yajima N, Kawahara K, Sasaki M, Tsuchiya N, Enomoto K, Mak TW, Nakano T, Habuchi T, Suzuki A, Hyperplasia and Carcinomas in Pten-Deficient Mice and Reduced PTEN Protein in Human Bladder Cancer Patients. Cancer Res. 2006 Sep 1;66(17):8389-96

MGI:5789953
注：该品系与Stk11-Flox(2)(NM-CKO-200251)和Cyp1a1-cre/ERT工具鼠交配才可能获得预期表型

Shorning BY, Griffiths D, Clarke AR, Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS One. 2011;6(1):e16209

MGI:3844324
注：该品系与P53-Flox(2)(NM-CKO-190067)和Adeno-cre工具鼠交配才可能获得预期表型

Puzio-Kuter AM, Castillo-Martin M, Kinkade CW, Wang X, Shen TH, Matos T, Shen MM, Cordon-Cardo C, Abate-Shen C, Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev. 2009 Mar 15;23(6):675-80

MGI:4882033
注：该品系与Tyr-cre工具鼠交配才可能获得预期表型

Puig I, Champeval D, De Santa Barbara P, Jaubert F, Lyonnet S, Larue L, Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction. J Clin Invest. 2009 Dec;119(12):3586-96

MGI:5503192
注：该品系与Twist2-Cre工具鼠交配才可能获得预期表型

Tiozzo C, Carraro G, Al Alam D, Baptista S, Danopoulos S, Li A, Lavarreda-Pearce M, Li C, De Langhe S, Chan B, Borok Z, Bellusci S, Minoo P, Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov 1;122(11):3862-72

MGI:5660888
注：该品系与Eno2-cre工具鼠交配才可能获得预期表型

Kwon CH, Luikart BW, Powell CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF, Pten regulates neuronal arborization and social interaction in mice. Neuron. 2006 May 4;50(3):377-88

MGI:4840094
注：该品系与Nf1-Flox(NM-CKO-200018)，P53-Flox(2)(NM-CKO-190067)和GFAP-cre工具鼠交配才可能获得预期表型

Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF, Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 2008 May 1;68(9):3286-94

MGI:4941746
注：该品系与Ctnnb1-Flox(NM-CKO-200154)和Amhr2-Cre工具鼠交配才可能获得预期表型

Boyer A, Paquet M, Lague MN, Hermo L, Boerboom D, Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis. Carcinogenesis. 2009 May;30(5):869-78

MGI:4418448
注：该品系与Cdkn2a-Flox(2)(NM-CKO-200151)和Tyr-cre/ERT2工具鼠交配才可能获得预期表型

Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW, Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 1;70(1):388-97

MGI:4418449
注：该品系与Cdkn2a-Flox(2)(NM-CKO-200151)，Ctnnb1-Flox(NM-CKO-200154)和Tyr-cre/ERT2工具鼠交配才可能获得预期表型

Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW, Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 1;70(1):388-97

MGI:5784778
注：该品系与Hras-Flox(NM-CKO-2117376)和TPO-cre工具鼠交配才可能获得预期表型

Garcia-Rendueles ME, Ricarte-Filho JC, Untch BR, Landa I, Knauf JA, Voza F, Smith VE, Ganly I, Taylor BS, Persaud Y, Oler G, Fang Y, Jhanwar SC, Viale A, Heguy A, Huberman KH, Giancotti F, Ghossein R, Fagin JA, NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition. Cancer Discov. 2015 Nov;5(11):1178-93

MGI:5897837
注：该品系与P53-Flox(2)(NM-CKO-190067)和TPO-cre工具鼠交配才可能获得预期表型

Antico Arciuch VG, Russo MA, Dima M, Kang KS, Dasrath F, Liao XH, Refetoff S, Montagna C, Di Cristofano A, Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors. Oncotarget. 2011 Dec;2(12):1109-26

MGI:4838317
注：该品系与TPO-cre工具鼠交配才可能获得预期表型

Antico-Arciuch VG, Dima M, Liao XH, Refetoff S, Di Cristofano A, Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females. Oncogene. 2010 Oct 21;29(42):5678-86

MGI:5517709
注：该品系与Nkx2-1-cre工具鼠交配才可能获得预期表型

Tiozzo C, Danopoulos S, Lavarreda-Pearce M, Baptista S, Varimezova R, Al Alam D, Warburton D, Rehan V, De Langhe S, Di Cristofano A, Bellusci S, Minoo P, Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr;19(2):111-22

MGI:5897675
注：该品系与Prkar1a-Flox(NM-CKO-2101183))和TPO-cre工具鼠交配才可能获得预期表型

Pringle DR, Yin Z, Lee AA, Manchanda PK, Yu L, Parlow AF, Jarjoura D, La Perle KM, Kirschner LS, Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer. Endocr Relat Cancer. 2012 Jun;19(3):435-46

MGI:5432226
注：该品系与Ctnnb1-Flox(NM-CKO-200154)和CYP19A1-cre工具鼠交配才可能获得预期表型

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

MGI:5432232
注：该品系与Pten-Flox(NM-CKO-18004)和Amhr2-Cre工具鼠交配才可能获得预期表型

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

MGI:5704363
注：该品系与Dicer1-Flox(NM-CKO-200158)和Amhr2-Cre工具鼠交配才可能获得预期表型

Kim J, Coffey DM, Creighton CJ, Yu Z, Hawkins SM, Matzuk MM, High-grade serous ovarian cancer arises from fallopian tube in a mouse model. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3921-6

MGI:5704370
注：该品系与Dicer1-Flox(NM-CKO-200158)，P53-Flox(2)(NM-CKO-190067)和Amhr2-Cre工具鼠交配才可能获得预期表型

Kim J, Coffey DM, Ma L, Matzuk MM, The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice. Endocrinology. 2015 Jun;156(6):1975-81

MGI:5704372
注：该品系与P53-Flox(2)(NM-CKO-190067)和Amhr2-Cre工具鼠交配才可能获得预期表型

Kim J, Coffey DM, Ma L, Matzuk MM, The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice. Endocrinology. 2015 Jun;156(6):1975-81

MGI:5779541
注：该品系与Apc-Flox(NM-CKO-200013)和Ad-Cre工具鼠交配才可能获得预期表型

Wu R, Hendrix-Lucas N, Kuick R, Zhai Y, Schwartz DR, Akyol A, Hanash S, Misek DE, Katabuchi H, Williams BO, Fearon ER, Cho KR, Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell. 2007 Apr;11(4):321-33

MGI:5902132
注：该品系与Braf-Flox(NM-CKO-200073)和Tyr-cre/ERT2工具鼠交配才可能获得预期表型

Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE Jr, You MJ, DePinho RA, McMahon M, Bosenberg M, Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet. 2009 May;41(5):544-52

MGI:4358249
注：该品系与Pbsn-cre工具鼠交配才可能获得预期表型

Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, Plaisier S, Garraway IP, Huang J, Graeber TG, Wu H, Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth. Cancer Cell. 2011 Jun 14;19(6):792-804

MGI:4420974
注：该品系与Pbsn-cre工具鼠交配才可能获得预期表型

Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H, Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003 Sep;4(3):209-21

MGI:5009703
注：该品系与Ar-Flox(NM-CKO-00110)和Pbsn-cre工具鼠交配才可能获得预期表型

Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, Plaisier S, Garraway IP, Huang J, Graeber TG, Wu H, Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth. Cancer Cell. 2011 Jun 14;19(6):792-804

MGI:5431978
注：该品系与Tert-Flox(NM-CKO-2114953)，P53-Flox(2)(NM-CKO-190067)和Pbsn-cre工具鼠交配才可能获得预期表型

Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA, Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell. 2012 Mar 2;148(5):896-907

MGI:5467305
注：该品系与Spry1-Flox(NM-CKO-2100607)，Spry2-Flox(NM-CKO-2100890)和Osr1-cre工具鼠交配才可能获得预期表型

Schutzman JL, Martin GR, Sprouty genes function in suppression of prostate tumorigenesis. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20023-8

MGI:5543907
注：该品系与Braf-Flox(NM-CKO-200073)和Nkx3-1-Cre工具鼠交配才可能获得预期表型

Wang J, Kobayashi T, Floc'h N, Kinkade CW, Aytes A, Dankort D, Lefebvre C, Mitrofanova A, Cardiff RD, McMahon M, Califano A, Shen MM, Abate-Shen C, B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer. Cancer Res. 2012 Sep 15;72(18):4765-76

MGI:5636613
注：该品系与KLK3-cre工具鼠交配才可能获得预期表型

De Velasco MA, Tanaka M, Yamamoto Y, Hatanaka Y, Koike H, Nishio K, Yoshikawa K, Uemura H, Androgen deprivation induces phenotypic plasticity and promotes resistance to molecular targeted therapy in a PTEN-deficient mouse model of prostate cancer. Carcinogenesis. 2014 Sep;35(9):2142-53

MGI:5705321
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Pbsn-cre工具鼠交配才可能获得预期表型

Mulholland DJ, Kobayashi N, Ruscetti M, Zhi A, Tran LM, Huang J, Gleave M, Wu H, Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. Cancer Res. 2012 Apr 1;72(7):1878-89

MGI:5827768
注：该品系与Pbsn-cre工具鼠交配才可能获得预期表型

Su Q, Zhang B, Zhang L, Dang T, Rowley D, Ittmann M, Xin L, Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene. 2017 Feb 02;36(5):618-627

MGI:4839510
注：该品系与Erbb2-Flox(NM-CKO-2100231)和MMTV-cre工具鼠交配才可能获得预期表型

Dourdin N, Schade B, Lesurf R, Hallett M, Munn RJ, Cardiff RD, Muller WJ, Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis. Cancer Res. 2008 Apr 1;68(7):2122-31

MGI:5752193
注：该品系与P53-Flox(2)(NM-CKO-190067)和MMTV-cre工具鼠交配才可能获得预期表型

Liu JC, Voisin V, Wang S, Wang DY, Jones RA, Datti A, Uehling D, Al-awar R, Egan SE, Bader GD, Tsao M, Mak TW, Zacksenhaus E, Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. EMBO Mol Med. 2014 Dec;6(12):1542-60

MGI:5752196
注：该品系与P53-Flox(2)(NM-CKO-190067)和Wap-cre工具鼠交配才可能获得预期表型

Liu JC, Voisin V, Wang S, Wang DY, Jones RA, Datti A, Uehling D, Al-awar R, Egan SE, Bader GD, Tsao M, Mak TW, Zacksenhaus E, Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. EMBO Mol Med. 2014 Dec;6(12):1542-60

MGI:4849441
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Gfap-cre工具鼠交配才可能获得预期表型

Gregorian C, Nakashima J, Dry SM, Nghiemphu PL, Smith KB, Ao Y, Dang J, Lawson G, Mellinghoff IK, Mischel PS, Phelps M, Parada LF, Liu X, Sofroniew MV, Eilber FC, Wu H, PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19479-84

MGI:5812676
注：该品系与Sdhb-Flox(NM-CKO-2102409)和KLK3-cre工具鼠交配才可能获得预期表型

Lepoutre-Lussey C, Thibault C, Buffet A, Morin A, Badoual C, Benit P, Rustin P, Ottolenghi C, Janin M, Castro-Vega LJ, Trapman J, Gimenez-Roqueplo AP, Favier J, From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma. Mol Cell Endocrinol. 2016 Feb 5;421:40-8

MGI:5825466
注：该品系与P53-Flox(2)(NM-CKO-190067)和Nes-cre/ERT2工具鼠交配才可能获得预期表型

Zhu G, Rankin SL, Larson JD, Zhu X, Chow LM, Qu C, Zhang J, Ellison DW, Baker SJ, PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation. Cancer Res. 2017 Jan 01;77(1):123-133

MGI:5487550
注：该品系与Tgfbr1-Flox(NM-CKO-200142)和KRT14-cre/ERT工具鼠交配才可能获得预期表型

Sun ZJ, Zhang L, Hall B, Bian Y, Gutkind JS, Kulkarni AB, Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model. Clin Cancer Res. 2012 Oct 1;18(19):5304-13

MGI:5013917
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Pdx1-cre工具鼠交配才可能获得预期表型

Hill R, Calvopina JH, Kim C, Wang Y, Dawson DW, Donahue TR, Dry S, Wu H, PTEN loss accelerates KrasG12D-induced pancreatic cancer development. Cancer Res. 2010 Sep 15;70(18):7114-24

MGI:5787929
注：该品系与Nf1-Flox(NM-CKO-200018)和Mx1-cre工具鼠交配才可能获得预期表型

Liu YL, Yan Y, Webster C, Shao L, Lensing SY, Ni H, Feng W, Colorado N, Pathak R, Xiang Z, Hauer-Jensen M, Li S, Zhou D, Emanuel PD, Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy. Blood. 2016 Apr 14;127(15):1912-22

MGI:3813633
注：该品系与Pgr-Cre工具鼠交配才可能获得预期表型

Daikoku T, Hirota Y, Tranguch S, Joshi AR, DeMayo FJ, Lydon JP, Ellenson LH, Dey SK, Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res. 2008 Jul 15;68(14):5619-27

MGI:4944273
注：该品系与Errfi1-Flox(NM-CKO-2101042))和Pgr-Cre工具鼠交配才可能获得预期表型

Kim TH, Franco HL, Jung SY, Qin J, Broaddus RR, Lydon JP, Jeong JW, The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. Oncogene. 2010 Jul 1;29(26):3770-80