Tfam-Flox

品系全名

C57BL/6JSmo-Tfamtm1(flox)Smoc

目录号

NM-CKO-200173

品系状态

活体

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基因信息

基因名
Tfam

基因曾用名

Hmgts; mtTFA; tsHMG; AI661103

NCBI ID

21780

MGI ID

107810

Ensembl ID

ENSMUSG00000003923

Pubmed

Tfam

人类同源基因

TFAM

品系描述

在Tfam基因exon 6-7两侧分别插入loxP位点，建立Tfam基因条件性敲除小鼠模型。
应用领域：激活的PKN1刺激AR（雄激素受体）调节基因KLK2和KLK3的转录以及线粒体基因表达相关研究

疾病预测

Kearns-Sayre 综合征
Kearns-Sayre Syndrome

近似模型的表型

MGI:2177634
注：该品系与Ckmm-cre工具鼠交配才可能获得预期表型

参考文献

Wang J, Wilhelmsson H, Graff C, Li H, Oldfors A, Rustin P, Bruning JC, Kahn CR, Clayton DA, Barsh GS, Thoren P, Larsson NG, Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet. 1999 Jan;21(1):133-7

帕金森病
Parkinson's Disease

近似模型的表型

MGI:3702932
注：该品系与Slc6a3-cre工具鼠交配才可能获得预期表型

参考文献

Ekstrand MI, Terzioglu M, Galter D, Zhu S, Hofstetter C, Lindqvist E, Thams S, Bergstrand A, Hansson FS, Trifunovic A, Hoffer B, Cullheim S, Mohammed AH, Olson L, Larsson NG, Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30

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