Rag1-KO(Rag1-EGFP)
品系全名
B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
目录号
NM-KI-00069
品系状态
活体
基因信息
基因名
Rag1
品系描述
验证数据
Fig.1 Construction strategy of Rag1-KO.
Fig.2 Loss of T and B cells in peripheral blood of Rag1-KO and Rag2-KO mice.
Fig.3 Loss of T and B cells in Spleen of Rag1-KO and Rag2-KO mice.
Fig.4 Loss of T and B cells in thymus of Rag1-KO and Rag2-KO mice.
Fig.5 Detection of EGFP expression in CD45+ cells in spleen, blood, thymus, and bone marrow of 8.7-week-old female WT and HO Rag1-KO(Rag1-EGFP) mice.
Fig.6 Detection of mouse IgG(A) and IgM(B) expression in serum by ELISA. (male, 5~6wks, n=3)
Abbr. HO, homozygous; WT, wild type; N.D. not detected.
Fig.7 Tumorigenicity results following inoculation with A549 tumor cells in Balb/c nude, NOD-Scid, Rag1-KO and Rag2-KO mice.
Table1. Complete blood count of Rag1-KO (Rag1-EGFP) mice
Table 2. Serum biochemical analysis of Rag1-KO (Rag1-EGFP) mice.
发表文献 11篇
你也可能感兴趣
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
查看
