Cdh5-2A-tdTomato-IRES-CreERT2

该品系由中山大学中山眼科中心许跃捐赠，发表文献时需注明：Cdh5-2A-tdTomato-IRES-CreERT2 mice (Cat. NO. NM-KI-242750) were purchased from Shanghai Model Organisms Center, Inc. (SMOC). This strain was donated to SMOC by Yue Xu from Zhongshan Ophthalmic Center, Sun Yat-sen University.

Fig1. Immunofluorescence staining with an anti-CD31 antibody in the Blood vessels of Cdh5^{tdTomato-IRES-CreERT2/+}; R26^{CAG-LSL-zsGreen/+}mice revealed the co-expression of CD31 and zsGreen.

Fig2. Detection of tdTomato(red) and zsGreen(green) in various tissues of Cdh5^{tdTomato-IRES-CreERT2/+}; R26^{CAG-LSL-zsGreen/+} mice. 

After Tamoxifen induction, zsGreen-expressing tissues include: brain, kidney, eye, lung, spleen, liver, large intestine, small intestine, vagina, thymus, salivary gland, stomach, reproductive system, skin, muscle, pancreas, pituitary gland, and adrenal gland.

tdTomato-expressing tissues include: spleen, vagina, thymus, stomach, reproductive system, and skin.Tissues with low tdTomato expression: large intestine, and small intestine.

Without Tamoxifen induction, tissues with leaky zsGreen expression include: eye, spleen, large intestine, reproductive system, and pituitary gland. tdTomato-expressing tissues include: spleen, and thymus.

Mouse age: 89 days, Female.