Lipa-KO

品系全名

C57BL/6Smoc-Lipaem1Smoc

目录号

NM-KO-201298

品系状态

活体

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基因信息

基因名
Lipa

品系描述

敲除Lipa基因exon 3,建立Lipa基因敲除小鼠模型。曾有基因修饰致死报导,详情点击基因信息中的MGI ID。

疾病预测

沃尔曼病
Wolman Disease

验证数据

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Fig.1 Body weight of Lipa-KO and WT C57BL/6 mice. (2~4 month: n=3~6; 6 month: n=1~3)image.png

Fig.2 ALT and AST of Lipa-KO and WT C57BL/6 mice. (2~4 month: n=3~6; 6 month: n=1~3)

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Fig.3 Blood lipid profile of Lipa-KO and WT C57BL/6 mice. (2~4 month: n=3~6; 6 month: n=1~3)

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Fig.4 Cholesterol content of Lipa-KO and WT C57BL/6 mice in liver and spleen. (n=1~3).

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Fig.5 Gross pathology and relative weight of liver of Lipa-KO and WT C57BL/6 mice. (n=1~3).

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Fig. 6 Gross pathology and relative weight of spleen of Lipa-KO and WT C57BL/6 mice. (n=1~3).

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Fig.7 Gross pathology and relative weight of small intestine of Lipa-KO and WT C57BL/6 mice. (n=1~3).

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Fig.8 Relative weight of WAT of Lipa-KO and WT C57BL/6 mice. (n=1~3).

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Fig.9 Representative oil‐red‐staining images of liver and spleen of of 3-month old mice Lipa-KO and WT C57BL/6 mice. 

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Fig.10 Representative pictures of liver and spleen of 3-month old mice Lipa-KO and WT C57BL/6 mice. 

Macrophages (orange arrow), fibroblast proliferation (brown arrow), and granulocyte infiltration (red arrow).


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