Tagln-Cre

品系全名

C57BL/6JSmo-Taglnem1(Cre-WPRE-polyA)Smoc

目录号

NM-KI-200144

品系状态

活体

导出PDF

基因信息

基因名
Tagln

基因曾用名

Sm22; Sm22a; Ws310

染色体位置

9

NCBI ID

21345

MGI ID

106012

Ensembl ID

ENSMUSG00000032085

Pubmed

Tagln

品系描述

将Cre-WPRE-polyA插入到小鼠Tagln基因起始密码子处。 该基因编码平滑肌细胞特异性细胞骨架蛋白，当与含有loxP位点侧翼序列的小鼠品系杂交时，cre介导的重组会导致血管平滑肌细胞中侧翼序列的缺失。在动脉粥样硬化小鼠模型中，该基因产物可能参与动脉粥样硬化发生过程中的斑块细胞和动脉粥样硬化病变的形成。
应用领域：Cre工具鼠，血管平滑肌细胞

验证数据

image.png

图 1 TaglnCre/+; Rosa26tdTomato/+小鼠胚胎中tdTomato的表达情况。

TaglnCre/+; Rosa26tdTomato/+双转基因鼠，可在E11.5小鼠胚胎的血管中检测到tdTomato的表达。image.png

图 2 TaglnCre/+; Rosa26tdTomato/+小鼠肺部tdTomato的表达情况。

TaglnCre/+; Rosa26tdTomato/+双转基因鼠，可在小鼠在肺血管平滑肌细胞中检测到tdTomato的表达。

image.png

图 3 TaglnCre/+; Rosa26tdTomato/+小鼠各组织中tdTomato的表达情况。TdTomato的表达在大脑，眼，心，肝，肺，肌肉，胰腺，睾丸及附睾，唾液腺，脾，胸腺大量表达。在大肠，小肠，肾，皮肤有少量表达。而在棕色脂肪，胃有零星表达。（更多详细信息请联系我司技术顾问。）


发表文献 2篇

1. Cell type-specific contribution of low-density lipoprotein receptor to atherosclerosis
发表年份：2026 来源杂志：Science China-Life Sciences

2. Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis
发表年份：2022 来源杂志：EXPERIMENTAL AND MOLECULAR MEDICINE

展开

你也可能感兴趣

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

查看

Workshop：Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

查看

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

查看