Foxj1-2A-tdTomato-2A-CreERT2
品系全名
C57BL/6Smoc-Foxj1em1(P2A-tdTomato-T2A-CreERT2-WPRE-pA)Smoc
目录号
NM-KI-242431
品系状态
精子冻存
基因信息
基因名
Foxj1
品系描述
验证数据

Fig1. CreERT2 mediated recombination in spinal cord of Foxj1CreERT2-2A-tdTomato/+; Rosa26zsGreen/+ mouse.
Fig2. CreERT2 mediated recombination in lung of Foxj1CreERT2-2A-tdTomato/+; Rosa26zsGreen/+ mouse.

Fig3. Detection of zsGreen(Green) and tdTomato(red) in various tissues of Foxj1CreERT2-2A-tdTomato/+; Rosa26zsGreen/+ mouse. Following tamoxifen induction, zsGreen expression was observed in the brain, spinal cord, lungs, kidneys, trachea, and uterine adnexa. In the absence of tamoxifen induction, low-level leaky expression of zsGreen was detected in the brain, spinal cord, lungs, trachea, and uterine adnexa. tdTomato expression was detected in the brain, spinal cord, lungs, trachea, and uterine adnexa, with no significant expression observed in other tissues. (92-days old, male, 117-days old, female) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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