HBV-Tg

品系全名

B6.Cg-Tg(HBV)Smoc

目录号

NM-TG-00003

品系状态

活体

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品系描述

将c1型HBV病毒1.0拷贝全长DNA转入小鼠，该转基因小鼠血清中HBsAg呈阳性，但无HBeAg、anti-HBs、anti-HBe或antiHBc表达，无HBV DNA复制。在该转基因小鼠模型的血清、肝脏和肾脏中可以检测到稳定表达的人乙肝病毒表面抗原，该小鼠模型为研究人类“乙型肝炎”的发病机制、治疗方法与药物筛选，提供了理想的动物模型和新型研究手段，具有重要的医药应用价值。
应用领域：乙型肝炎

验证数据

HBV-1.png

Fig1. Immuno-histochemical staining of HBsAg in the liver and kidney sections of #59 transgenic mice. Sections of liver (A) or kidney (B) tissues from #59 transgenic mice were stained for HBsAg.

HBV-2.png

Fig2.  Immuno-histochemical staining of HBcAg in the liver and kidney sections of #59 transgenic mice.

Sections of liver (A) or kidney (B) tissues from #59 transgenic mice were stained for HBcAg.

HBV-3.png

Tab1. Eight Selected Genes From the Kidney of #59 Mice Assayed by Microarray and Real-Time PCR

HBV-4.png

Fig3.  Dot blot immunoassay of complement C3 component in mouse serum and kidney tissue extract.

Reference

1. Ren J, Wang L, Chen Z, Ma ZM, Zhu HG, Yang DL, Li XY, Wang BI, Fei J, Wang ZG, Wen YM. Gene expression profile of transgenic mouse kidney reveals pathogenesis of hepatitis B virus associated nephropathy. J Med Virol. 2006 May;78(5):551-60. doi: 10.1002/jmv.20575. PMID: 16555286.

发表文献 12篇

1. Intratumoral bacterium Enterocloster bolteae promotes hepatocellular carcinoma progression by directly binding tumor cells
发表年份：2026 来源杂志：Cell Host & Microbe

2. Hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression
发表年份：2024 来源杂志：Science Bulletin

3. Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication
发表年份：2023 来源杂志：JOURNAL OF MEDICAL VIROLOGY

4. The therapeutic effect of IL-21 combined with IFN-γ inducing CD4+CXCR5+CD57+T cells differentiation on hepatocellular carcinoma
发表年份：2021 来源杂志：Journal of Advanced Research

5. Breaking Hepatitis B Virus Tolerance and Inducing Protective Immunity Based on Mimicking T Cell-Independent Antigen
发表年份：2016 来源杂志：VIRAL IMMUNOLOGY

6. Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection
发表年份：2015 来源杂志：JOURNAL OF IMMUNOLOGY

7. Anti-Hepatitis B Virus Effect and Possible Mechanism of Action of 3,4-O-Dicaffeoylquinic Acid In Vitro and In Vivo
发表年份：2012 来源杂志：Evidence-based Complementary and Alternative Medicine

8. Transcriptional analysis of immune-related genes in dendritic cells from hepatitis B surface antigen (HBsAg)-positive transgenic mice and regulation of Fc gamma receptor IIB by HBsAg-anti-HBs complex
发表年份：2011-01-01 来源杂志：Journal of Medical Virology

9. Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection
发表年份：2010-04-01 来源杂志：Journal of Virology

10. An Altered Pattern of Liver Apolipoprotein A-I Isoforms Is Implicated in Male Chronic Hepatitis B Progression
发表年份：2010-01-09 来源杂志：ACS Publications

11. Proteomic analysis of hepatitis B surface antigen positive transgenic mouse liver and decrease of cyclophilin A
发表年份：2007-10-01 来源杂志：Journal of Medical Virology

12. Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver
发表年份：2007-09-10 来源杂志：JOURNAL OF HEPATOLOGY

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