Nos1-KO

品系全名

C57BL/6JSmo-Nos1em1Smoc

目录号

NM-KO-240406

品系状态

精子冻存

导出PDF

基因信息

基因名
Nos1

基因曾用名

NO; NOS; bNOS; nNOS; N-NOS; NOS-I; Nos-1; NC-NOS; 2310005C01Rik

NCBI ID

18125

MGI ID

97360

Ensembl ID

ENSMUSG00000029361

Pubmed

Nos1

人类同源基因

NOS1

品系描述

通过敲除Nos1基因exon 1，建立Nos1基因敲除小鼠模型。

疾病预测

贲门失弛缓症
Achalasia

近似模型的表型

MGI:3618910

参考文献

Sivarao DV, Mashimo HL, Thatte HS, Goyal RK, Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice. Gastroenterology. 2001 Jul;121(1):34-42

肥厚型心肌病
Hypertrophic Cardiomyopathy

近似模型的表型

MGI:4367213
注：该品系需与Nos3-KO(NM-KO-18022)交配才可能获得预期表型

参考文献

Barouch LA, Cappola TP, Harrison RW, Crone JK, Rodriguez ER, Burnett AL, Hare JM, Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice. J Mol Cell Cardiol. 2003 Jun;35(6):637-44

肥厚性幽门狭窄
Hypertrophic Pyloric Stenosis

近似模型的表型

MGI:2174975

参考文献

Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC, Targeted disruption of the neuronal nitric oxide synthase gene. Cell. 1993 Dec 31;75(7):1273-86

肾性尿崩症
Nephrogenic Diabetes Insipidus

近似模型的表型

MGI:3789190
注：该品系需与Nos2-KO(NM-KO-18027)和Nos3-KO(NM-KO-18022)交配才可能获得预期表型

参考文献

Morishita T, Tsutsui M, Shimokawa H, Sabanai K, Tasaki H, Suda O, Nakata S, Tanimoto A, Wang KY, Ueta Y, Sasaguri Y, Nakashima Y, Yanagihara N, Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10616-21

鉴定报告

下载

你也可能感兴趣

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

查看

Workshop：Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

查看

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

查看