Stk11-Flox

品系全名

C57BL/6JSmo-Stk11tm(flox)1Smoc

目录号

NM-CKO-18014

品系状态

活体

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基因信息

基因名
Stk11

基因曾用名

Lkb1; Par-4; R75140; AA408040

NCBI ID

20869

MGI ID

1341870

Ensembl ID

ENSMUSG00000003068

Pubmed

Stk11

人类同源基因

STK11

品系描述

flox Stk11基因exon3-6。可与组织特异性Cre工具鼠交配，在表达Cre酶的细胞中，条件性敲除 Stk11基因。该品系带有Neo筛选基因。

疾病预测

子宫内膜癌
Endometrial Cancer

近似模型的表型

MGI:4438263
注：该品系与Sprr2f-cre工具鼠交配才可能获得预期表型

参考文献

Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, Bardeesy N, Takahashi M, Settleman J, Wong KK, Castrillon DH, Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Model Mech. 2010 Mar-Apr;3(3-4):181-93

Peutz-Jeghers 综合征
Peutz-Jeghers Syndrome

近似模型的表型

MGI:3814590
注：该品系与Pdx1-cre工具鼠交配才可能获得预期表型

参考文献

Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA, Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol. 2008 Apr;28(7):2414-25

Peutz-Jeghers 综合征
Peutz-Jeghers Syndrome

近似模型的表型

MGI:3814722
注：该品系与KRT14-cre工具鼠交配才可能获得预期表型

参考文献

Gurumurthy S, Hezel AF, Berger JH, Bosenberg MW, Bardeesy N, LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res. 2008 Jan 1;68(1):55-63

Peutz-Jeghers 综合征
Peutz-Jeghers Syndrome

近似模型的表型

MGI:5440238
注：该品系与Amhr2-Cre工具鼠交配才可能获得预期表型

参考文献

Tanwar PS, Kaneko-Tarui T, Zhang L, Teixeira JM, Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis. Hum Mol Genet. 2012 Oct 15;21(20):4394-405

皮肤黑色素瘤
Skin Melanoma

近似模型的表型

MGI:5752239
注：该品系与Cdkn2a-Flox(2)(NM-CKO-200151)，Nras-Flox(NM-CKO-2100519)和Tyr-cre/ERT2工具鼠交配才可能获得预期表型

参考文献

Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, Sharpless NE, Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discov. 2014 Dec;4(12):1418-29

膀胱癌
Urinary Bladder Cancer

近似模型的表型

MGI:5789953
注：该品系与Pten-Flox(NM-CKO-18004)和Cyp1a1-cre/ERT工具鼠交配才可能获得预期表型

参考文献

Shorning BY, Griffiths D, Clarke AR, Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS One. 2011;6(1):e16209

发表文献 2篇

1. Oncoprotein SET-associated transcription factor ZBTB11 triggers lung cancer metastasis
发表年份：2024 来源杂志：Nature Communications

2. Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy
发表年份：2023 来源杂志：Nature Communications

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