hCFB
品系全名
C57BL/6Smoc-Cfbtm1(hCFB)/Smoc
目录号
NM-HU-2000078
品系状态
活体
基因信息
基因名
品系描述
通过同源重组,将小鼠Cfb基因进行人源化修饰。
验证数据
Fig1. Detection of CFB expression in liver by RT-PCR.
Wild type: only one band at 441 bp with primers F1/R1(mCfb);
Homozygous: only one band at 442 bp with primers F2/R2(hCFB);
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig2. Detection of human and mouse CFB expression in serum by ELISA (n=2).
Abbr. HO, homozygous; WT, wild type.
Note: The mouse CFB ELISA kit cross-reacted with mCFB and humanized CFB.
Fig3. Detection of liver CFB mRNA remaining at Day 7 (A) and serum protein level (B) after single dose of test drug (n=3/group). (Data from a collaborator)
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