Tmem173-Flox

品系全名

B6;129S-Tmem173tm1(flox)Smoc

目录号

NM-CKO-00014

品系状态

活体

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品系描述

分别于3号外显子之前和5号外显子后插入loxp位点。若与Cre品系小鼠交配的后代可在Cre酶表达的组织中条件性敲除该基因。 去除neo基因状态活体。
应用领域:细胞凋亡、免疫应答等免疫系统相关研究

发表文献 15篇

1. ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury
发表年份:2025 来源杂志:Clinical and Translational Medicine

2. cGAS/STING signalling in macrophages aggravates obliterative bronchiolitis via an IFN-α-dependent mechanism after orthotopic tracheal transplantation in mice
发表年份:2025 来源杂志:Clinical and Translational Medicine

3. ELF4 improves sepsis-induced myocardial injury by regulating STING signaling-mediated T cells differentiation
发表年份:2025 来源杂志:CELL BIOLOGY AND TOXICOLOGY

4. Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitis
发表年份:2024 来源杂志:Theranostics

5. Deletion of stimulator of interferons genes aggravated cardiac dysfunction in physiological aged mice
发表年份:2024 来源杂志:MECHANISMS OF AGEING AND DEVELOPMENT

6. Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury
发表年份:2023 来源杂志:Military Medical Research

7. Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury
发表年份:2023 来源杂志:Advanced Science

8. STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease
发表年份:2023 来源杂志:MOLECULAR THERAPY

9. Original research: Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation
发表年份:2023 来源杂志:Journal for ImmunoTherapy of Cancer

10. Smad4 Deficiency Promotes Pancreatic Cancer Immunogenicity by Activating the Cancer-Autonomous DNA-Sensing Signaling Axis
发表年份:2022 来源杂志:Advanced Science

11. A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion
发表年份:2022 来源杂志:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

12. XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression
发表年份:2022 来源杂志:JHEP Reports

13. Mitochondrial Damage-Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease-Associated Plaque Vulnerability
发表年份:2021 来源杂志:Advanced Science

14. Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling
发表年份:2021 来源杂志:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

15. Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors
发表年份:2020 来源杂志:Advanced Science

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