模型资源
- 成品模型
- 工具小鼠
- Find Cre 工具鼠
- 报告基因工具鼠
- 荧光示踪小鼠
- 其他报告基因工具鼠
- 基因调控工具鼠
- 四环素调控工具鼠
- 疾病小鼠(U-DMbase®)
- 自发肿瘤小鼠模型
- 罕见病小鼠模型
- 传染病研究模型
- 神经系统疾病模型
- 代谢心血管疾病模型
- 自身免疫疾病模型
- 免疫学研究小鼠
- 免疫靶点人源化小鼠
- 免疫缺陷小鼠
- 免疫细胞标记小鼠
- 细胞因子示踪小鼠
- 免疫细胞剔除小鼠
- 人源化小鼠
- 肿瘤靶点
- 免疫检查点
- 补体系统靶点
- 细胞因子
- 细胞因子受体
- 代谢靶点
- 病毒感染受体
- 其他靶点
- 常规基因修饰模型
- 全身敲除小鼠
- 条件性敲除小鼠
- 过表达小鼠
- 点突变小鼠
- 敲入小鼠
- 大鼠模型资源库
- 免疫缺陷大鼠
- 人源化大鼠
- 荧光示踪大鼠
- 疾病模型
- 工具大鼠
- 细胞系
- 其他细胞系
- 原代细胞系
- 人源化细胞系
- 荧光细胞系
- 野生型细胞系
- 常规小鼠品系
- 远交系(封闭群)小鼠
- 近交系小鼠
BALB/c
品系全名
BALB/cAnSmoc
目录号
SM-003
品系状态
活体
品系描述
BALB/c小鼠毛色白化,是生物医学研究中使用最广泛的近交系模型之一,特别是在免疫学和传染病研究中应用广泛。乳腺肿瘤发生率约为10%~20%。有一定数量的卵巢、肾上腺和肺部肿瘤、白血病的发生。肺癌发病率雌性26%,雄性29%。白血病发病率雌性12%,雄性10%。血压与其他近交系小鼠相比为最高,有自发高血压症。
验证数据

图1. BALB/c小鼠血常规检测。
发表文献 68篇
1.
Celastrol induces ferroptosis in ccRCC through TEF-Driven ACOX2 upregulation and metabolic reprogramming
发表年份:2026
来源杂志:PHYTOMEDICINE
2.
Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy
发表年份:2025
来源杂志:Nature Communications
3.
Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics
发表年份:2025
来源杂志:Nature Communications
4.
Hypoxia-responsive oncolytic conjugate triggers type-II immunogenic cell death for enhanced photodynamic immunotherapy
发表年份:2025
来源杂志:JOURNAL OF CONTROLLED RELEASE
5.
Live biotherapeutic enterococcus lactis MNC-168 promotes the efficacy of immune checkpoint blockade in cancer therapy by activating STING pathway via bacterial membrane vesicles
发表年份:2025
来源杂志:Gut Microbes
6.
DYRK1A-TGF-β signaling axis determines sensitivity to OXPHOS inhibition in hepatocellular carcinoma
发表年份:2025
来源杂志:DEVELOPMENTAL CELL
7.
Enhancing vaccine half-life as a novel strategy for improving immune response durability of subunit vaccines
发表年份:2025
来源杂志:PLoS Pathogens
8.
APG-115 Induces SLC7A11-Mediated Ferroptosis and Upregulates PD-L1 Expression in Thyroid Cancer
发表年份:2025
来源杂志:ACS Omega
9.
Early growth response 2 activates MAF bZIP transcription factor F to protect β-cells from oxidative stress in type 1 diabetes
发表年份:2025
来源杂志:TISSUE & CELL
10.
Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
发表年份:2024
来源杂志:Bioactive Materials
11.
Fully human single-domain antibody targeting a highly conserved cryptic epitope on the Nipah virus G protein
发表年份:2024
来源杂志:Nature Communications
12.
NIR-II light-activated and Cu nanocatalyst-enabled bioorthogonal reaction in living systems for efficient tumor therapy
发表年份:2024
来源杂志:Nano Today
13.
Oncolytic Peptide-Nanoplatform Drives Oncoimmune Response and Reverses Adenosine-Induced Immunosuppressive Tumor Microenvironment
发表年份:2024
来源杂志:Advanced Healthcare Materials
14.
Chaperonin-containing TCP1 subunit 6A inhibition via TRIM21-mediated K48-linked ubiquitination suppresses triple-negative breast cancer progression through the AKT signalling pathway
发表年份:2024
来源杂志:Clinical and Translational Medicine
15.
Protection against DSS-induced colitis in mice through FcεRIα deficiency: the role of altered Lactobacillus
发表年份:2024
来源杂志:npj Biofilms and Microbiomes
16.
Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response
发表年份:2024
来源杂志:Cell Reports
17.
Mining and multifaceted applications of phage lysin for combatting Vibrio parahaemolyticus
发表年份:2024
来源杂志:FOOD RESEARCH INTERNATIONAL
18.
Signals from intestinal microbiota mediate the crosstalk between the lung-gut axis in an influenza infection mouse model
发表年份:2024
来源杂志:Frontiers in Immunology
19.
Ginsenoside reprogramming microglia through the FGF/FGFR1 inhibits post traumatic stress disorder
发表年份:2024
来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY
20.
SLC4A4 as a novel biomarker involved in immune system response and lung adenocarcinoma progression
发表年份:2024
来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY
21.
Simple ROS-responsive micelles loaded Shikonin for efficient ovarian cancer targeting therapy by disrupting intracellular redox homeostasis
发表年份:2024
来源杂志:EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
22.
Engineered Probiotic-mediated Intratumoral Delivery and Controlled Release of Bacterial Collagenase for Cancer Therapy
发表年份:2024
来源杂志:Synthetic and Systems Biotechnology
23.
Jiedu recipe, a compound Chinese herbal medicine, suppresses hepatocellular carcinoma metastasis by inhibiting the release of tumor-derived exosomes in a hypoxic microenvironment
发表年份:2024
来源杂志:Journal of Integrative Medicine-JIM
24.
CHES1 modulated tumorigenesis and senescence of pancreas cancer cells through repressing AKR1B10
发表年份:2024
来源杂志:BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
25.
Serum metabolomic profiling reveals potential biomarkers in systemic sclerosis
发表年份:2023
来源杂志:METABOLISM-CLINICAL AND EXPERIMENTAL
26.
Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist
发表年份:2023
来源杂志:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
27.
A quinazoline derivative suppresses B cell hyper-activation and ameliorates the severity of systemic lupus erythematosus in mice
发表年份:2023
来源杂志:Frontiers in Pharmacology
28.
CCL17 acts as an antitumor chemokine in micromilieu‐driven immune skewing
发表年份:2023
来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY
29.
Transcriptomics and systems network-based molecular mechanism of herbal formula Huosu-Yangwei inhibited gastric cancer in vivo
发表年份:2023
来源杂志:JOURNAL OF ETHNOPHARMACOLOGY
30.
Anti-Leukemia Activity of Polysaccharide from Sargassum fusiforme via the PI3K/AKT/BAD Pathway In Vivo and In Vitro
发表年份:2023
来源杂志:Marine Drugs
31.
Chromatin Remodelling Molecule ARID1A Determines Metastatic Heterogeneity in Triple-Negative Breast Cancer by Competitively Binding to YAP
发表年份:2023
来源杂志:Cancers
32.
Overexpression of RAB31 in gastric cancer is associated with released exosomes and increased tumor cell invasion and metastasis
发表年份:2023
来源杂志:Cancer Medicine
33.
Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury
发表年份:2023
来源杂志:CELL TRANSPLANTATION
34.
Polymer chimera of stapled oncolytic peptide coupled with anti-PD-L1 peptide boosts immunotherapy of colorectal cancer
发表年份:2022
来源杂志:Theranostics
35.
Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
发表年份:2022
来源杂志:JCI Insight
36.
Candidalysin, a Virulence Factor of Candida albicans, Stimulates Mast Cells by Mediating Cross-Talk Between Signaling Pathways Activated by the Dectin-1 Receptor and MAPKs
发表年份:2022
来源杂志:JOURNAL OF CLINICAL IMMUNOLOGY
37.
Mechanism of erythropoietin-induced M2 microglia polarization via Akt / Mtor / P70S6k signaling pathway in the treatment of brain injury in premature mice and its effect on biofilm
发表年份:2022
来源杂志:Bioengineered
38.
Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury
发表年份:2022
来源杂志:Frontiers in Pharmacology
39.
Emergence of mcr-8.2-harboring hypervirulent ST412 Klebsiella pneumoniae strain from pediatric sepsis: A comparative genomic survey
发表年份:2022
来源杂志:Virulence
40.
Sulfuretin exerts anti-depressive effects in the lipopolysaccharide-induced depressive mouse models
发表年份:2022
来源杂志:PHYSIOLOGY & BEHAVIOR
41.
Up-regulated FNDC1 accelerates stemness and chemoradiation resistance in colorectal cancer cells
发表年份:2022
来源杂志:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
42.
Resveratrol Attenuates Ankylosing Spondylitis in Mice by Inhibiting the TLR4/NF-κB/NLRP3 Pathway and Regulating Gut Microbiota
发表年份:2022
来源杂志:IMMUNOLOGICAL INVESTIGATIONS
43.
Construction of two new photoluminescent 3D heterometallic complexes and their nursing application values on ICU infection
发表年份:2022
来源杂志:POLYMER BULLETIN
44.
Nootkatone Improves Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors by Repressing NF-κB/NLRP3-Mediated Neuroinflammation
发表年份:2022
来源杂志:Chinese Journal of Integrative Medicine
45.
Treatment and nursing values of a new mixed-ligand In(III)-based complex on acute ischemic stroke
发表年份:2022
来源杂志:JOURNAL OF THE INDIAN CHEMICAL SOCIETY
46.
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells
发表年份:2021
来源杂志:MOLECULAR CELL
47.
Biomimetic cytomembrane nanovaccines prevent breast cancer development in the long term
发表年份:2021
来源杂志:Nanoscale
48.
Ablation of Survivin in T Cells Attenuates Acute Allograft Rejection after Murine Heterotopic Heart Transplantation by Inducing Apoptosis
发表年份:2021
来源杂志:Frontiers in Immunology
49.
Accumulation of CD45RO+CD8+ T cells is a diagnostic and prognostic biomarker for clear cell renal cell carcinoma
发表年份:2021
来源杂志:Aging-US
50.
lncRNA OIP5-AS1 Suppresses Cell Proliferation and Invasion of Endometrial Cancer by Regulating PTEN/AKT via Sponging miR-200c-3p
发表年份:2021
来源杂志:Journal of Immunology Research
51.
Enzyme-linked immunosorbent assays for quantification of MMAE-conjugated ADCs and total antibodies in cynomolgus monkey sera
发表年份:2021
来源杂志:Journal of Pharmaceutical Analysis
52.
Hsa_circ_0004712 downregulation attenuates ovarian cancer malignant development by targeting the miR-331-3p/FZD4 pathway
发表年份:2021
来源杂志:Journal of Ovarian Research
53.
Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
发表年份:2021
来源杂志:IMMUNOLOGICAL INVESTIGATIONS
54.
Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro
发表年份:2021
来源杂志:JOURNAL OF APPLIED TOXICOLOGY
55.
Transcriptional profiling and network pharmacology analysis identify the potential biomarkers from Chinese herbal formula Huosu Yangwei Formula treated gastric cancer in vivo
发表年份:2021
来源杂志:Chinese Journal of Natural Medicines
56.
LINC00261 relieves the progression of sepsis-induced acute kidney injury by inhibiting NF-κB activation through targeting the miR-654-5p/SOCS3 axis
发表年份:2021
来源杂志:JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
57.
Six1 Promotes Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells via the TGFβ1/Smad Signalling Pathway
发表年份:2021
来源杂志:INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
58.
Assembly of two mixed-ligand Co(II) complexes: crystal structures and protective activity on acute myocardial infarction
发表年份:2021
来源杂志:Journal of the Iranian Chemical Society
59.
Extracellular vesicles engineered with valency-controlled DNA nanostructures deliver CRISPR/Cas9 system for gene therapy
发表年份:2020
来源杂志:NUCLEIC ACIDS RESEARCH
60.
Autophagy-lysosome inhibitor chloroquine prevents CTLA-4 degradation of T cells and attenuates acute rejection in murine skin and heart transplantation
发表年份:2020
来源杂志:Theranostics
61.
Alveolar macrophage - derived exosomes modulate severity and outcome of acute lung injury
发表年份:2020
来源杂志:Aging-US
62.
Longevity Effect of Liuwei Dihuang in Both Caenorhabditis Elegans and Aged Mice
发表年份:2019
来源杂志:Aging and Disease
63.
Ameliorative effect of acetylshikonin on ovalbumin (OVA)-induced allergic rhinitis in mice through the inhibition of Th2 cytokine production and mast cell histamine release
发表年份:2019
来源杂志:APMIS
64.
Downregulation of homeobox gene Barx2 increases gastric cancer proliferation and metastasis and predicts poor patient outcomes
发表年份:2016
来源杂志:Oncotarget
65.
MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression
发表年份:2016
来源杂志:Oncotarget
66.
FeS nanoplates as a multifunctional nano-theranostic for magnetic resonance imaging guided photothermal therapy
发表年份:2014
来源杂志:BIOMATERIALS
67.
Functional Core/Shell Drug Nanoparticles for Highly Effective Synergistic Cancer Therapy
发表年份:2014
来源杂志:Advanced Healthcare Materials
68.
Smart Nanorods for Highly Effective Cancer Theranostic Applications
发表年份:2013
来源杂志:Advanced Healthcare Materials
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