R26-ZsGreen-DTA

品系全名

C57BL/6JSmo-Gt(ROSA)26Sortm(CAG-ZsGreen,-DTA)1Smoc

目录号

NM-KI-225002

品系状态

活体

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基因信息

基因名
Gt(ROSA)26Sor

品系描述

该小鼠含有正向的ZsGreen和反向的DTA序列,被lox位点(包括反向的两个lox2272和反向的两个loxP)间隔开来。在没有Cre重组酶的情况下,ZsGreen受到CAG启动子的控制,小鼠全身都可以观察到荧光。一旦有Cre重组酶介入,将DTA序列调转过来,可以剔除表达Cre的细胞。使用该种结构,可以避免DTA在没有Cre酶存在情况下提前泄露。

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