历年文献基因敲除小鼠_转基因小鼠定制

                            
                            HHEX–PRKAR2B Axis-Mediated PKA Activation Drives Glucose Metabolism-Dependent Progression of Pancreatic Ductal Adenocarcinoma
                        

产品名称：KPC-luc; C57BL/6

研究领域：肿瘤; 代谢; 胰导管腺癌

发表年份：2026 发表杂志：iScience

                            
                            Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN-MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age
                        

产品名称：Xcr1-KO

研究领域：高龄妊娠; 滋养层细胞; 蜕膜多核型髓源抑制性细胞

发表年份：2026 发表杂志：Advanced Science

                            
                            Discovery of Oxime Ether Derivatives as Second-Generation PRMT5 Inhibitors for the Treatment of Triple Negative Breast Cancer
                        

产品名称：M-NSG

研究领域：乳腺癌

发表年份：2026 发表杂志：JOURNAL OF MEDICINAL CHEMISTRY

                            
                            Multi-omics analysis identifies BUB1B as a cell cycle–related driver of bladder cancer progression
                        

产品名称：BALB/c nude

研究领域：膀胱癌

发表年份：2026 发表杂志：World Journal of Surgical Oncology

                            
                            HDAC3 Mediates Hippocampal Microglial Pyroptosis Via the STING/NLRP3 Pathway and Contributes To Cognitive Impairment in Sepsis-Associated Encephalopathy
                        

产品名称：Cx3cr1-Cre

研究领域：败血症相关脑病; 小胶质细胞

发表年份：2026 发表杂志：INFLAMMATION

Lipid-induced granules in hepatocytes alleviate liver fibrosis

产品名称：Alb-Cre

研究领域：肝纤维化; 无膜细胞器;

发表年份：2026 发表杂志：Cell Metabolism

                            
                            Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells
                        

产品名称：Piezo1-Flox

研究领域：造血干细胞

发表年份：2026 发表杂志：CELL RESEARCH

                            
                            Mesenchymal stromal cells counteract with age-related immune decline and enhance vaccine efficacy by modulating endogenous splenic marginal reticular cells in elderly models
                        

产品名称：Madcam1-T2A-tdTomato-P2A-CreERT2

研究领域：免疫; 脾脏微环境; 疫苗应答

发表年份：2026 发表杂志：Cellular & Molecular Immunology

                            
                            Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome-Mediated Colitis and Mood Disorder
                        

产品名称：Cx3cr1-CreERT2

研究领域：NLRP3炎症小体; 慢性炎症性疾病

发表年份：2026 发表杂志：Advanced Science

                            
                            PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1-KDM5C-IL6 Axis in ccRCC
                        

产品名称：Pbrm1-Flox; Vhl-Flox

研究领域：肾透明细胞癌; 肿瘤免疫逃逸

发表年份：2026 发表杂志：Advanced Science

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HHEX–PRKAR2B Axis-Mediated PKA Activation Drives Glucose Metabolism-Dependent Progression of Pancreatic Ductal Adenocarcinoma

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN-MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Discovery of Oxime Ether Derivatives as Second-Generation PRMT5 Inhibitors for the Treatment of Triple Negative Breast Cancer

Multi-omics analysis identifies BUB1B as a cell cycle–related driver of bladder cancer progression

HDAC3 Mediates Hippocampal Microglial Pyroptosis Via the STING/NLRP3 Pathway and Contributes To Cognitive Impairment in Sepsis-Associated Encephalopathy

Lipid-induced granules in hepatocytes alleviate liver fibrosis

Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells

Mesenchymal stromal cells counteract with age-related immune decline and enhance vaccine efficacy by modulating endogenous splenic marginal reticular cells in elderly models

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome-Mediated Colitis and Mood Disorder

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1-KDM5C-IL6 Axis in ccRCC

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