历年文献基因敲除小鼠_转基因小鼠定制

                            
                            Hint2 deficiency aggravates mitochondria-associated ferroptosis in lung ischemia-reperfusion injury
                        

产品名称：Hint2-Flox

研究领域：肺缺血-再灌注损伤; 铁死亡

发表年份：2026 发表杂志：iScience

                            
                            Kaempferol in Jichuan decoction alleviates slow-transit constipation by attenuating oxidative stress-induced interstitial cells of Cajal apoptosis: A network pharmacological study
                        

产品名称：C57BL/6

研究领域：慢性便秘; 氧化应激

发表年份：2026 发表杂志：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

                            
                            NFATC1 dysfunction-triggered MSC senescence induces tooth aging amenable to senolytic therapy
                        

产品名称：C57BL/6

研究领域：MSC衰老; 牙齿衰老

发表年份：2026 发表杂志：Stem Cell Reports

                            
                            Targeting ADAR1 p150 triggers tumor inhibition and antitumor immunity to overcome immunotherapy resistance
                        

产品名称：KPC

研究领域：肿瘤; 肿瘤免疫治疗

发表年份：2026 发表杂志：iScience

                            
                            Functional Precision Oncology Platform of BRAFV600E-Mutated Colorectal Cancer Organoids Predicts Therapy Response and Reveals RNF43-Mediated Immunogenicity
                        

产品名称：M-NSG

研究领域：结直肠癌;功能性精准肿瘤学;免疫原性预测

发表年份：2026 发表杂志：DRUG RESISTANCE UPDATES

                            
                            LSM7 coordinates scaRNA-mediated snRNA modification to ensure spliceosome fidelity and spermatogonial stem cell differentiation
                        

产品名称：Lsm7-flox

研究领域：snRNA修饰;剪接体保真度;精原干细胞分化;RNA剪切调控

发表年份：2026 发表杂志：CELL DEATH AND DIFFERENTIATION

                            
                            G protein-coupled receptor 75 mediates depression-like behaviors and HPA axis hyperactivity through an excitatory arcuate-paraventricular nucleus circuit
                        

产品名称：Vglut2-CreERT2

研究领域：抑郁症;HPA轴;弓状核-室旁核环路;兴奋性神经传递;下丘脑神经肽

发表年份：2026 发表杂志：ACTA PHARMACOLOGICA SINICA

                            
                            Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain
                        

产品名称：TrkB2A-Tomato

研究领域：慢性神经病理性疼痛;超分子活性复合物;镇痛;疼痛靶点

发表年份：2026 发表杂志：Advanced Science

                            
                            A Non-Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non-Small Cell Lung Cancer
                        

产品名称：饲养繁育

研究领域：非小细胞肺癌;奥希替尼耐药;非经典转录调控回路;染色质重编程

发表年份：2026 发表杂志：Advanced Science

                            
                            FBXW7α regulates amyloid pathology by mediating ubiquitination and degradation of BACE1 in Alzheimer’s disease
                        

产品名称：5×FAD

研究领域：阿尔茨海默病;BACE1泛素化降解;β-淀粉样蛋白;蛋白酶体系统;蛋白稳态

发表年份：2026 发表杂志：Cell Death Discovery

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Hint2 deficiency aggravates mitochondria-associated ferroptosis in lung ischemia-reperfusion injury

Kaempferol in Jichuan decoction alleviates slow-transit constipation by attenuating oxidative stress-induced interstitial cells of Cajal apoptosis: A network pharmacological study

NFATC1 dysfunction-triggered MSC senescence induces tooth aging amenable to senolytic therapy

Targeting ADAR1 p150 triggers tumor inhibition and antitumor immunity to overcome immunotherapy resistance

Functional Precision Oncology Platform of BRAFV600E-Mutated Colorectal Cancer Organoids Predicts Therapy Response and Reveals RNF43-Mediated Immunogenicity

LSM7 coordinates scaRNA-mediated snRNA modification to ensure spliceosome fidelity and spermatogonial stem cell differentiation

G protein-coupled receptor 75 mediates depression-like behaviors and HPA axis hyperactivity through an excitatory arcuate-paraventricular nucleus circuit

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

A Non-Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non-Small Cell Lung Cancer

FBXW7α regulates amyloid pathology by mediating ubiquitination and degradation of BACE1 in Alzheimer’s disease

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