R26-CAG-LNL-CaMPARI

品系全名

C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LNL-CaMPARI)-NSmoc

目录号

NM-KI-00090

品系状态

胚胎冻存

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基因信息

基因名
Gt(ROSA)26Sor

品系描述

在Rosa26基因位点定点插入CAG-LNL-CaMPARI表达框。杂合子小鼠无明显异常。LNL的存在阻止了下游目的基因CaMPARI的转录。目的基因CaMPARI的表达部位及效率,取决于Cre表达的组织类型和效率。CaMPARI基因Rosa26位点条件性过表达小鼠与Cre小鼠交配后,在其后代双阳性小鼠中,Cre表达的组织和细胞类型,LNL结构将被敲除,目的基因CaMPARI表达。
应用领域:神经系统

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