Lmx1b-Flox

品系全名

C57BL/6JSmo-Lmx1bem1(flox)Smoc

目录号

NM-CKO-200117

品系状态

胚胎冻存

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基因信息

基因名
Lmx1b

基因曾用名

Icst; LMX1.1; LMX1.2

NCBI ID

16917

MGI ID

1100513

Ensembl ID

ENSMUSG00000038765

Pubmed

Lmx1b

人类同源基因

LMX1B

品系描述

在Lmx1b基因exon 4-6两侧分别插入loxP位点，建立Lmx1b基因条件性敲除小鼠模型。
应用领域：多巴胺能神经发生和婴儿猝死综合症（SIDS）易感性途径相关研究

疾病预测

帕金森病
Parkinson's Disease

近似模型的表型

MGI:5647883
注：该品系与Lmx1a-Flox(NM-CKO-2114850)和Slc6a3-cre工具鼠交配才可能获得预期表型

参考文献

Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen JK, Gomez-Galan M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T, Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci. 2015 Jun;18(6):826-35

指甲-髌骨综合征
Nail-Patella Syndrome

近似模型的表型

MGI:3715141
注：该品系与NPHS2-cre工具鼠交配才可能获得预期表型

参考文献

Suleiman H, Heudobler D, Raschta AS, Zhao Y, Zhao Q, Hertting I, Vitzthum H, Moeller MJ, Holzman LB, Rachel R, Johnson R, Westphal H, Rascle A, Witzgall R, The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes. Dev Biol. 2007 Apr 15;304(2):701-12

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