Pdgfrb-Flox

品系全名

C57BL/6JSmo-Pdgfrbtm1(flox)Smoc

目录号

NM-CKO-200204

品系状态

精子冻存

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基因信息

基因名
Pdgfrb

基因曾用名

Pdgfr; CD140b; PDGFR-1; AI528809

NCBI ID

18596

MGI ID

97531

Ensembl ID

ENSMUSG00000024620

Pubmed

Pdgfrb

人类同源基因

PDGFRB

品系描述

在Pdgfrb基因exon 3-7两侧分别插入loxP位点，建立Pdgfrb基因条件性敲除小鼠模型。
应用领域：RET信号传导和B细胞受体（BCR）的下游信号传导事件相关研究

疾病预测

自闭症谱系障碍
Autism Spectrum Disorder

近似模型的表型

MGI:5790635
注：该品系与Nes-cre工具鼠交配才可能获得预期表型

参考文献

Nakamura T, Matsumoto J, Takamura Y, Ishii Y, Sasahara M, Ono T, Nishijo H, Relationships among parvalbumin-immunoreactive neuron density, phase-locked gamma oscillations, and autistic/schizophrenic symptoms in PDGFR-beta knock-out and control mice. PLoS One. 2015;10(3):e0119258

发表文献 1篇

1. Aneurysm Is Restricted by CD34+ Cell-Formed Fibrous Collars Through the PDGFRb-PI3K Axis
发表年份：2024 来源杂志：Advanced Science

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