Ctnnb1-Flox

品系全名

C57BL/6Smoc-Ctnnb1em1(flox)Smoc

目录号

NM-CKO-200154

品系状态

精子冻存

导出PDF

基因信息

基因名
Ctnnb1

基因曾用名

Bfc， Mesc， Catnb

NCBI ID

12387

MGI ID

88276

Ensembl ID

ENSMUSG00000006932

Pubmed

Ctnnb1

基因标记细胞类型举例 

脾脏单核细胞、肾脏集合管瞬态细胞

人类同源基因

CTNNB1

人类同源基因关联疾病 

卵巢癌、髓母细胞瘤

品系描述

通过Crispr/Cas9基因编辑技术，在Ctnnb1基因exon 2-6两侧分别插入loxP位点，建立Ctnnb1基因条件性敲除小鼠模型。
应用领域：心肌细胞肥大中的MicroRNA和CDK介导的磷酸化和Cdc6的去除相关研究

疾病预测

膀胱癌
Urinary Bladder Cancer

近似模型的表型

MGI:5790498
注：该品系与Cdkn1a-Flox(NM-CKO-200033)和Upk2-cre工具鼠交配才可能获得预期表型

参考文献

Ahmad I, Patel R, Liu Y, Singh LB, Taketo MM, Wu XR, Leung HY, Sansom OJ, Ras mutation cooperates with beta-catenin activation to drive bladder tumourigenesis. Cell Death Dis. 2011;2:e124

膀胱癌
Urinary Bladder Cancer

近似模型的表型

MGI:5790500
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Upk2-cre工具鼠交配才可能获得预期表型

参考文献

Ahmad I, Patel R, Liu Y, Singh LB, Taketo MM, Wu XR, Leung HY, Sansom OJ, Ras mutation cooperates with beta-catenin activation to drive bladder tumourigenesis. Cell Death Dis. 2011;2:e124

肺癌
Lung Cancer

近似模型的表型

MGI:5141741
注：该品系与Fgfr3-Flox(NM-CKO-2101148)和Upk2-cre工具鼠交配才可能获得预期表型

参考文献

Ahmad I, Singh LB, Foth M, Morris CA, Taketo MM, Wu XR, Leung HY, Sansom OJ, Iwata T, K-Ras and {beta}-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Dis Model Mech. 2011 Jul-Aug;4(4):548-55

睾丸颗粒细胞瘤
Testicular Granulosa Cell Tumor

近似模型的表型

MGI:4941746
注：该品系与Pten-Flox(NM-CKO-18004)和Amhr2-Cre工具鼠交配才可能获得预期表型

参考文献

Boyer A, Paquet M, Lague MN, Hermo L, Boerboom D, Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis. Carcinogenesis. 2009 May;30(5):869-78

黑色素瘤
Melanoma

近似模型的表型

MGI:4418449
注：该品系与Cdkn2a-Flox(2)(NM-CKO-200151)，Pten-Flox(NM-CKO-18004)和Tyr-cre/ERT2工具鼠交配才可能获得预期表型

参考文献

Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW, Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 1;70(1):388-97

卵巢癌
Ovarian Cancer

近似模型的表型

MGI:5432223
注：该品系与CYP19A1-cre工具鼠交配才可能获得预期表型

参考文献

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

卵巢癌
Ovarian Cancer

近似模型的表型

MGI:5432224
注：该品系与Kras-LSL-G12D(NM-KI-190003)和CYP19A1-cre工具鼠交配才可能获得预期表型

参考文献

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

卵巢癌
Ovarian Cancer

近似模型的表型

MGI:5432226
注：该品系与Pten-Flox(NM-CKO-18004)和CYP19A1-cre工具鼠交配才可能获得预期表型

参考文献

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

卵巢癌
Ovarian Cancer

近似模型的表型

MGI:5432228
注：该品系与Amhr2-Cre工具鼠交配才可能获得预期表型

参考文献

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

卵巢癌
Ovarian Cancer

近似模型的表型

MGI:5432231
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Amhr2-Cre工具鼠交配才可能获得预期表型

参考文献

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

卵巢癌
Ovarian Cancer

近似模型的表型

MGI:5432232
注：该品系与Ctnnb1-Flox(NM-CKO-200154)和Amhr2-Cre工具鼠交配才可能获得预期表型

参考文献

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

前列腺癌
Prostate Cancer

近似模型的表型

MGI:3836579
注：该品系与Pbsn-cre工具鼠交配才可能获得预期表型

参考文献

Pearson HB, Phesse TJ, Clarke AR, K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Res. 2009 Jan 1;69(1):94-101

唾液腺癌
Salivary Gland Carcinoma

近似模型的表型

MGI:5508218
注：该品系与Bmpr1a-Flox(NM-CKO-2100038)和KRT14-cre工具鼠交配才可能获得预期表型

参考文献

Wend P, Fang L, Zhu Q, Schipper JH, Loddenkemper C, Kosel F, Brinkmann V, Eckert K, Hindersin S, Holland JD, Lehr S, Kahn M, Ziebold U, Birchmeier W, Wnt/beta-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. EMBO J. 2013 Jul 17;32(14):1977-89

中耳炎
Otitis Media

近似模型的表型

MGI:3706580
注：该品系与CMV-cre工具鼠交配才可能获得预期表型

参考文献

Schmidt-Ullrich R, Aebischer T, Hulsken J, Birchmeier W, Klemm U, Scheidereit C, Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development. 2001 Oct;128(19):3843-53

自闭症谱系障碍
Autism Spectrum Disorder

近似模型的表型

MGI:5812797
注：该品系与Pvalb-cre工具鼠交配才可能获得预期表型

参考文献

Dong F, Jiang J, McSweeney C, Zou D, Liu L, Mao Y, Deletion of CTNNB1 in inhibitory circuitry contributes to autism-associated behavioral defects. Hum Mol Genet. 2016 Jul 1;25(13):2738-2751

你也可能感兴趣

Tamoxifen诱导Cre-ERT2小鼠 使用指南

Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。

查看
【小鼠大学问】基因工程小鼠的命名规则

常见的基因工程小鼠可以分为两种命名方式，包括基因定点修饰的小鼠命名，比如：敲除、敲入、点突变等等，和随机转基因的小鼠命名。

查看