Slc6a4-Cre

品系全名

C57BL/6JSmo-Slc6a4em1(iCre-pA)Smoc

目录号

NM-KI-200115

品系状态

精子冻存

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基因信息

基因名
Slc6a4

品系描述

将iCre-pA插入到小鼠Slc6a4基因起始密码子处。 Slc6a4-Cre与含有 loxP 侧翼序列的小鼠交配,Cre 介导的重组后将导致后代Slc6a4阳性细胞中 floxed 序列的缺失。该基因产物与成瘾、抑郁等神经疾病相关。
应用领域:Cre工具鼠

验证数据

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图 1 Slc6a4Cre/+; Rosa26tdTomato/+小鼠脑部中tdTomato的表达情况。

Slc6a4Cre/+; Rosa26tdTomato/+双转基因鼠,可在小鼠皮层、丘脑、嗅球中检测到tdTomato的表达。

image.png

图 2 Slc6a4Cre/+; Rosa26tdTomato/+小鼠各组织中tdTomato的表达情况。TdTomato的表达可在脑的皮层和丘脑、心脏、支气管、肝脏、胃、唾液腺、表皮、睾丸、肾、胸腺和脾脏的个别细胞、胰腺、小肠和大肠中检测到。不表达的组织有:视网膜、肌肉。(更多详细信息请联系我司技术顾问。)



发表文献 2篇

1. Serotonergic modulation of vigilance states in zebrafish and mice
发表年份:2024 来源杂志:Nature Communications

2. The role of 5-HTergic neuron activation in the rapid antidepressant-like effects of hypidone hydrochloride (YL-0919) in mice
发表年份:2024 来源杂志:Frontiers in Pharmacology

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