Itgam-IRES-hCD89
品系全名
C57BL/6Smoc-Itgamem1(IRES-hCD89-WPRE-polyA)Smoc
目录号
NM-KI-200063
品系状态
活体
基因信息
基因名
Itgam
品系描述
验证数据
Fig1. Expression characterization of hCD89 in homozygous Itgam-IRES-hCD89 knockin mice in C57BL/6 background.
Fig2. Urine protein detection of Itgam-IRES-hCD89 mice.
The urine protein of the mice was measured by visual urine protein test strip every 3 weeks. According to the degree of color development in the reaction area, the urine protein level is divided into negative (-), 15 mg/L (±), 30 mg/L (+), 100 mg/L (++), and 300 mg/L (+++) . The results showed that Itgam-IRES-hCD89 mice started to develop proteinuria between 9-15 weeks of age. (Data provided by partners)
Fig3. Analysis of serum creatinine levels in Itgam-IRES-hCD89 mice.
The serum creatinine level of the 24-week-old Itgam-IRES-hCD89 mice increased significently.(Data provided by partners)
Fig4. Analysis of IgA expression distribution. IgA deposition can be detected in the glomerulus and mesangial area of the renal tubules in the Itgam-IRES-hCD89 mice, but no deposition was found in the wild-type mice. (Data provided by partners)
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