hMASP2

品系全名

C57BL/6Smoc-Masp2em1(hMASP2)/Smoc

目录号

NM-HU-2000076

品系状态

活体

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基因信息

基因名
Masp2

品系描述

通过同源重组,将小鼠Masp2基因进行人源化修饰。
应用领域:免疫治疗;药物筛选

验证数据

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Fig1. Detection of MASP2 expression in liver by RT-PCR. Wild type: only one band at 479 bp with primers F1/R1(mMasp2);Homozygous: only one band at 338 bp with primers F2/R2(hMASP2); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig 2. Detection of hMASP2 expression in liver and kindey in HO hMASP2 mice by IHC. Abbr. HO, homozygous; WT, wild type.

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Fig 3. Detection of IgA expression in liver and kindey in HO hMASP2 mice by IHC. Abbr. HO, homozygous; WT, wild type.

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Fig 4. No obvious pathological features were found in liver and kindey in HO hMASP2 mice. Abbr. HO, homozygous; WT, wild type.

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Fig 5. Detection of mC3 expression in serum by ELISA.  Abbr. HO, homozygous; WT, wild type.


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