Dmd-KO

品系全名

C57BL/6JSmo-Dmdem3Smoc

目录号

NM-KO-200573

品系状态

活体

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基因信息

基因名
Dmd

基因曾用名

dys; mdx; pke; Dp71; Dp427; DXSmh7; DXSmh9

NCBI ID

13405

MGI ID

94909

Ensembl ID

ENSMUSG00000045103

Pubmed

Dmd

人类同源基因

DMD

品系描述

敲除Dmd基因exon 52，建立Dmd基因敲除小鼠模型。
应用领域：肌营养不良症

疾病预测

杜氏肌营养不良症
Duchenne Muscular Dystrophy

近似模型的表型

MGI:3573782

参考文献

Kudoh H, Ikeda H, Kakitani M, Ueda A, Hayasaka M, Tomizuka K, Hanaoka K, A new model mouse for Duchenne muscular dystrophy produced by 2.4Mb deletion of dystrophin gene using Cre-loxP recombination system. Biochem Biophys Res Commun. 2005 Mar 11;328(2):507-16

验证数据

Dmd-ko.png

图1. WB检测Dmd基因敲除小鼠中DMD蛋白在心脏组织中的表达。结果表明纯合子未检测到条带，无蛋白表达。

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