Tespa1-KO

品系全名

B6;129S-Tespa1tm1Smoc

目录号

NM-KO-00036

品系状态

胚胎冻存

导出PDF

基因信息

基因名
Tespa1

品系描述

基因敲除纯合子小鼠可能出现晚期胸腺细胞发育异常。
应用领域:造血系统、免疫系统相关研究

发表文献 6篇

1. Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway
发表年份:2020 来源杂志:Journal of Translational Medicine

2. Thymic-specific regulation of TCR signaling by Tespa1
发表年份:2019 来源杂志:Cellular & Molecular Immunology

3. Tespa1 Deficiency Dampens Thymus-Dependent B-Cell Activation and Attenuates Collagen-Induced Arthritis in Mice
发表年份:2018 来源杂志:Frontiers in Immunology

4. Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors
发表年份:2017 来源杂志:Nature Communications

5. Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell–mediated allergic response
发表年份:2014 来源杂志:JOURNAL OF EXPERIMENTAL MEDICINE

6. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
发表年份:2012 来源杂志:NATURE IMMUNOLOGY

展开

你也可能感兴趣

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

查看

Workshop:Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

查看

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

查看