Lep-KO

品系全名

B6;129S-Leptm1Smoc

目录号

NM-KO-00034

品系状态

胚胎冻存

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基因信息

基因名
Lep

品系描述

瘦素基因缺失小鼠是研究胰岛素抵抗、肥胖、II型糖尿病等疾病的重要工具。瘦素基因的突变或缺失会导致严重的肥胖、肥胖引起的性腺功能不足,并与II型糖尿病的发展密切相关。研究还发现瘦素与心血管功能相关。该小鼠通常也称为ob/ob小鼠
应用领域:胰岛素抵抗、肥胖、II型糖尿病等

疾病预测

2型糖尿病
Type 2 Diabetes Mellitus
非酒精性脂肪肝
Non-Alcoholic Fatty Liver Disease
肥胖
Obesity
腹部肥胖代谢综合征 1
Abdominal Obesity-Metabolic Syndrome 1
腹部肥胖代谢综合症
Abdominal Obesity-Metabolic Syndrome

验证数据

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Fig1. Body weight and Blood glucose monitoring of ob/ob mice.

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Fig2. Evaluation of Oral glucose tolerance test (OGTT) of female ob/ob mice. 

Abbr. HO, homozygous; WT, wild type. **, P ≤ 0.01.

Note. The tested ob/ob and C57BL/6 mice were 6 weeks old.

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Fig3. Detection of insulin levels in serum by ELISA. 

Abbr. Hom, homozygous; HE, heterozygous; WT, wild type.

Note. The tested ob/ob and C57BL/6 mice were 20 weeks old.

image.png

Fig4. H&E staining of the subcutaneous adipose tissue (SAT) in ob/ob mice. 

Abbr. HO, homozygous; WT, wild type; WAT, white adipose tissue; BAT, brown adipose tissue. 

Note. The tested ob/ob and C57BL/6 mice were 20 weeks old. Scale bar, 200 μm; magnification, × 20.

image.png

Fig5. Representative pictures of pancreas in ob/ob mice. 

These results suggested the inflammatory cell infiltration of the pancreas in ob/ob mice. 

Abbr. HO, homozygous; WT, wild type. 

Note. The tested ob/ob and C57BL/6 mice were 20 weeks old. Scale bar, 200 μm; magnification, × 10.


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