Trp53-Frox

MGI:5750594
注：该品系与CMV-cre工具鼠交配才可能获得预期表型

Van Nostrand JL, Brady CA, Jung H, Fuentes DR, Kozak MM, Johnson TM, Lin CY, Lin CJ, Swiderski DL, Vogel H, Bernstein JA, Attie-Bitach T, Chang CP, Wysocka J, Martin DM, Attardi LD, Inappropriate p53 activation during development induces features of CHARGE syndrome. Nature. 2014 Oct 9;514(7521):228-32

MGI:4840090
注：该品系与Nf1-Flox(NM-CKO-200018)和GFAP-cre工具鼠交配才可能获得预期表型

Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF, Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 2008 May 1;68(9):3286-94

MGI:4840094
注：该品系与Pten-Flox(NM-CKO-18004)，Nf1-Flox(NM-CKO-200018)和GFAP-cre工具鼠交配才可能获得预期表型

Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF, Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 2008 May 1;68(9):3286-94

MGI:4840095
注：该品系与Nf1-Flox(NM-CKO-200018)和GFAP-cre工具鼠交配才可能获得预期表型

Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF, Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 2008 May 1;68(9):3286-94

MGI:3844657
注：该品系与Pax3-Flox(NM-CKO-2101872)和Myf6-Cre工具鼠交配才可能获得预期表型

Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR, Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Dec 1;18(21):2614-26

MGI:5519094
注：该品系与Rb1-Flox(NM-CKO-18012)和Sp7-tTA,tetO-EGFP/cre工具鼠交配才可能获得预期表型

Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH, Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev. 2008 Jun 15;22(12):1662-76

MGI:5781001
注：该品系与Ptch1-Flox(NM-CKO-18015)和BGLAP-cre工具鼠交配才可能获得预期表型

Chan LH, Wang W, Yeung W, Deng Y, Yuan P, Mak KK, Hedgehog signaling induces osteosarcoma development through Yap1 and H19 overexpression. Oncogene. 2014 Oct 2;33(40):4857-66

MGI:5796166
注：该品系与Prkar1a-Flox(NM-CKO-2101183))，Rb1-Flox(NM-CKO-18012)和Col1a1-cre工具鼠交配才可能获得预期表型

Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R, RANKL blockade prevents and treats aggressive osteosarcomas. Sci Transl Med. 2015 Dec 9;7(317):317ra197

MGI:5796167
注：该品系与Rb1-Flox(NM-CKO-18012)，Prkar1a-Flox(NM-CKO-2101183)和Col1a1-cre工具鼠交配才可能获得预期表型

Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R, RANKL blockade prevents and treats aggressive osteosarcomas. Sci Transl Med. 2015 Dec 9;7(317):317ra197

MGI:5796169
注：该品系与Prkar1a-Flox(NM-CKO-2101183))和Col1a1-cre工具鼠交配才可能获得预期表型

Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R, RANKL blockade prevents and treats aggressive osteosarcomas. Sci Transl Med. 2015 Dec 9;7(317):317ra197

MGI:5784771
注：该品系与Hras-Flox(NM-CKO-2117376)和TPO-cre工具鼠交配才可能获得预期表型

Garcia-Rendueles ME, Ricarte-Filho JC, Untch BR, Landa I, Knauf JA, Voza F, Smith VE, Ganly I, Taylor BS, Persaud Y, Oler G, Fang Y, Jhanwar SC, Viale A, Heguy A, Huberman KH, Giancotti F, Ghossein R, Fagin JA, NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition. Cancer Discov. 2015 Nov;5(11):1178-93

MGI:5897837
注：该品系与Pten-Flox(NM-CKO-18004)和TPO-cre工具鼠交配才可能获得预期表型

Antico Arciuch VG, Russo MA, Dima M, Kang KS, Dasrath F, Liao XH, Refetoff S, Montagna C, Di Cristofano A, Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors. Oncotarget. 2011 Dec;2(12):1109-26

MGI:3849178
注：该品系与GFAP-cre工具鼠交配才可能获得预期表型

Wang Y, Yang J, Zheng H, Tomasek GJ, Zhang P, McKeever PE, Lee EY, Zhu Y, Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell. 2009 Jun 2;15(6):514-26

MGI:3849179
注：该品系与Nf1-Flox(NM-CKO-200018)和GFAP-cre工具鼠交配才可能获得预期表型

Wang Y, Yang J, Zheng H, Tomasek GJ, Zhang P, McKeever PE, Lee EY, Zhu Y, Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell. 2009 Jun 2;15(6):514-26

MGI:6296606
注：该品系与Cdh1-Flox(NM-CKO-18016)和Wap-cre工具鼠交配才可能获得预期表型

Derksen PW, Braumuller TM, van der Burg E, Hornsveld M, Mesman E, Wesseling J, Krimpenfort P, Jonkers J, Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice. Dis Model Mech. 2011 May-Jun;4(3):347-58

MGI:5298084
注：该品系与Kras-LSL-G12D(NM-KI-190003)和KRT14-cre/ERT工具鼠交配才可能获得预期表型

Lapouge G, Youssef KK, Vokaer B, Achouri Y, Michaux C, Sotiropoulou PA, Blanpain C, Identifying the cellular origin of squamous skin tumors. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7431-6

MGI:5618123
注：该品系与Dicer1-Flox(NM-CKO-200158)和KRT5-cre/PGR工具鼠交配才可能获得预期表型

Lyle S, Hoover K, Colpan C, Zhu Z, Matijasevic Z, Jones SN, Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice. PLoS One. 2014;9(6):e100920

MGI:5704370
注：该品系与Dicer1-Flox(NM-CKO-200158)，Pten-Flox(NM-CKO-18004)和Amhr2-Cre工具鼠交配才可能获得预期表型

Kim J, Coffey DM, Ma L, Matzuk MM, The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice. Endocrinology. 2015 Jun;156(6):1975-81

MGI:5704372
注：该品系与Pten-Flox(NM-CKO-18004)和Amhr2-Cre工具鼠交配才可能获得预期表型

Kim J, Coffey DM, Ma L, Matzuk MM, The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice. Endocrinology. 2015 Jun;156(6):1975-81

MGI:4819193
注：该品系与Brca2-Flox(NM-CKO-200014)和Pbsn-cre工具鼠交配才可能获得预期表型

Francis JC, McCarthy A, Thomsen MK, Ashworth A, Swain A, Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis. PLoS Genet. 2010;6(6):e1000995

MGI:5431978
注：该品系与Tert-Flox(NM-CKO-2114953)，Pten-Flox(NM-CKO-18004)和Pbsn-cre工具鼠交配才可能获得预期表型

Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA, Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell. 2012 Mar 2;148(5):896-907

MGI:3762186
注：该品系与Brca1-Flox(NM-CKO-18007)和KRT14-cre工具鼠交配才可能获得预期表型

Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers J, Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6

MGI:3831430
注：该品系与Brca2-Flox(NM-CKO-200014)和KRT14-cre工具鼠交配才可能获得预期表型

Jonkers J, Meuwissen R, van Der Gulden H, Peterse H, van Der Valk M, Berns A, Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 2001 Dec;29(4):418-25

MGI:5307256
注：该品系与Brca1-Flox(NM-CKO-18007)和KRT14-cre工具鼠交配才可能获得预期表型

Drost R, Bouwman P, Rottenberg S, Boon U, Schut E, Klarenbeek S, Klijn C, van der Heijden I, van der Gulden H, Wientjens E, Pieterse M, Catteau A, Green P, Solomon E, Morris JR, Jonkers J, BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance. Cancer Cell. 2011 Dec 13;20(6):797-809

MGI:5752193
注：该品系与Pten-Flox(NM-CKO-18004)和MMTV-cre工具鼠交配才可能获得预期表型

Liu JC, Voisin V, Wang S, Wang DY, Jones RA, Datti A, Uehling D, Al-awar R, Egan SE, Bader GD, Tsao M, Mak TW, Zacksenhaus E, Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. EMBO Mol Med. 2014 Dec;6(12):1542-60

MGI:5752196
注：该品系与Pten-Flox(NM-CKO-18004)和Wap-cre工具鼠交配才可能获得预期表型

Liu JC, Voisin V, Wang S, Wang DY, Jones RA, Datti A, Uehling D, Al-awar R, Egan SE, Bader GD, Tsao M, Mak TW, Zacksenhaus E, Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. EMBO Mol Med. 2014 Dec;6(12):1542-60

MGI:5759821
注：该品系与Wap-cre工具鼠交配才可能获得预期表型

Wijnhoven SW, Zwart E, Speksnijder EN, Beems RB, Olive KP, Tuveson DA, Jonkers J, Schaap MM, van den Berg J, Jacks T, van Steeg H, de Vries A, Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development. Cancer Res. 2005 Sep 15;65(18):8166-73

MGI:3652717
注：该品系与Xrcc4-Flox(NM-CKO-2100799)和Nes-cre工具鼠交配才可能获得预期表型

Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW, XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7378-83

MGI:3710322
注：该品系与Cdkn2c-Flox(NM-CKO-205110)和Nes-cre工具鼠交配才可能获得预期表型

Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF, The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev. 2005 Nov 15;19(22):2656-67

MGI:3804216
注：该品系与Rb1-Flox(NM-CKO-18012)和Gfap-cre工具鼠交配才可能获得预期表型

Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A, Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000 Apr 15;14(8):994-1004

MGI:3831340
注：该品系与Brca2-Flox(NM-CKO-200014)和Nes-cre工具鼠交配才可能获得预期表型

Frappart PO, Lee Y, Russell HR, Chalhoub N, Wang YD, Orii KE, Zhao J, Kondo N, Baker SJ, McKinnon PJ, Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1880-5

MGI:5825466
注：该品系与Pten-Flox(NM-CKO-18004)和Nes-cre/ERT2工具鼠交配才可能获得预期表型

Zhu G, Rankin SL, Larson JD, Zhu X, Chow LM, Qu C, Zhang J, Ellison DW, Baker SJ, PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation. Cancer Res. 2017 Jan 01;77(1):123-133

MGI:5634400
注：该品系与Cdh1-Flox(NM-CKO-18016)，Smad4-Flox(NM-CKO-18011)和Pdx1-cre工具鼠交配才可能获得预期表型

Park JW, Jang SH, Park DM, Lim NJ, Deng C, Kim DY, Green JE, Kim HK, Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis. Mol Cancer Res. 2014 Aug;12(8):1088-99

MGI:4940096
注：该品系与Kras-LSL-G12D(NM-KI-190003)，Brca2-Flox(NM-CKO-200014)和Pdx1-cre工具鼠交配才可能获得预期表型

Skoulidis F, Cassidy LD, Pisupati V, Jonasson JG, Bjarnason H, Eyfjord JE, Karreth FA, Lim M, Barber LM, Clatworthy SA, Davies SE, Olive KP, Tuveson DA, Venkitaraman AR, Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer. Cancer Cell. 2010 Nov 16;18(5):499-509

MGI:5635880
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Pdx1-cre工具鼠交配才可能获得预期表型

Masso-Valles D, Jauset T, Serrano E, Sodir NM, Pedersen K, Affara NI, Whitfield JR, Beaulieu ME, Evan GI, Elias L, Arribas J, Soucek L, Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma. Cancer Res. 2015 Apr 15;75(8):1675-81

MGI:5662454
注：该品系与Rb1-Flox(NM-CKO-18012)和Ren-cre工具鼠交配才可能获得预期表型

Glenn ST, Jones CA, Sexton S, LeVea CM, Caraker SM, Hajduczok G, Gross KW, Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma. Oncogene. 2014 Dec 11;33(50):5706-15

MGI:4941336
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Pdx1-cre工具鼠交配才可能获得预期表型

Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA, Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell. 2005 May;7(5):469-83

MGI:5308946
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Pdx1-cre工具鼠交配才可能获得预期表型

Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA, Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52

MGI:5308951
注：该品系与Kras-LSL-G12D(NM-KI-190003)，Cdkn2a-Flox(2)(NM-CKO-200151)和Pdx1-cre工具鼠交配才可能获得预期表型

Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA, Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52

MGI:6505560
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Pdx1-cre工具鼠交配才可能获得预期表型

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM, Tissue-Specific Oncogenic Activity of KRAS(A146T). Cancer Discov. 2019 Jun;9(6):738-755

MGI:5898453
注：该品系与Apc-Flox(NM-CKO-200013)和Pdx1-cre工具鼠交配才可能获得预期表型

Kuo TL, Weng CC, Kuo KK, Chen CY, Wu DC, Hung WC, Cheng KH, APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice. Oncogene. 2016 Apr 28;35(17):2223-34

MGI:2176786
注：该品系与Brca1-Flox(NM-CKO-18007)和MMTV-cre工具鼠交配才可能获得预期表型

Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L , Wynshaw-Boris A , Deng CX, Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation [see comments]. Nat Genet. 1999 May;22(1):37-43

MGI:5297134
注：该品系与Brca1-Flox(NM-CKO-18007)和MMTV-cre工具鼠交配才可能获得预期表型

Jones LP, Tilli MT, Assefnia S, Torre K, Halama ED, Parrish A, Rosen EM, Furth PA, Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer. Oncogene. 2008 Jan 31;27(6):794-802

MGI:5297135
注：该品系与Ccm2-Flox(NM-CKO-2101248)和Cdh5-cre/ERT2工具鼠交配才可能获得预期表型

Jones LP, Tilli MT, Assefnia S, Torre K, Halama ED, Parrish A, Rosen EM, Furth PA, Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer. Oncogene. 2008 Jan 31;27(6):794-802

MGI:5771805
注：该品系与Smarcb1-Flox(NM-CKO-190042)和GFAP-cre工具鼠交配才可能获得预期表型

Ng JM, Martinez D, Marsh ED, Zhang Z, Rappaport E, Santi M, Curran T, Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53. Cancer Res. 2015 Nov 1;75(21):4629-39

MGI:5604728
注：该品系与Cdh16-cre工具鼠交配才可能获得预期表型

Ikenberg K, Valtcheva N, Brandt S, Zhong Q, Wong CE, Noske A, Rechsteiner M, Rueschoff JH, Caduff R, Dellas A, Obermann E, Fink D, Fuchs T, Krek W, Moch H, Frew IJ, Wild PJ, KPNA2 is overexpressed in human and mouse endometrial cancers and promotes cellular proliferation. J Pathol. 2014 Oct;234(2):239-52