Oprk1-2A-Cre

品系全名

C57BL/6JSmo-Oprk1em1(2A-Cre)Smoc

目录号

NM-KI-200299

品系状态

活体

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基因信息

基因名
Oprk1

基因曾用名

KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1

NCBI ID

18387

MGI ID

97439

Ensembl ID

ENSMUSG00000025905

Pubmed

Oprk1

人类同源基因

OPRK1

品系描述

将2A-Cre插入到小鼠Oprk1基因终止密码子处。 Oprk1（opioid receptor, kappa 1）是阿片受体，多脑区表达。当与含有loxP位点侧翼序列的小鼠杂交时，cre介导的重组会导致表达细胞侧翼区域的缺失。阿片类受体的激活与记忆障碍有关，也在疼痛感知、镇痛和厌恶行为中发挥作用。
应用领域：Cre工具鼠，神经科学研究

验证数据

image.png

图 1 Oprk1Cre/+; Rosa26tdTomato/+小鼠脑部中tdTomato的表达情况。

Oprk1Cre/+; Rosa26tdTomato/+双转基因鼠，可在小鼠大脑中检测到tdTomato的表达。

image.png

图 2 Oprk1Cre/+; Rosa26tdTomato/+小鼠各组织中tdTomato的表达情况。TdTomato的表达还在肝、胃、小肠、大肠、骨骼肌、眼、心、脾、肺的部分细胞表达。不表达的组织有：唾液腺、棕色脂肪、真皮。（更多详细信息请联系我司技术顾问。）


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