hTIGIT/hPVR
品系全名
C57BL/6JSmo-Tigittm1(hTIGIT)Pvrtm1(hPVR)Smoc
目录号
NM-HU-2000091
品系状态
胚胎冻存
品系描述
验证数据
Fig.1 TIGIT&PVR双人源化纯合子小鼠通过尾静脉注射刀豆蛋白（9mg/kg）刺激6h，取脾脏细胞进行流式验证，检测 Tigit&Pvr 双人源化小鼠脾脏中人源 TIGIT 的表达。结果显示：TIGIT&PVR人源化纯合子小鼠脾脏的细胞中人源 TIGIT 表达活跃，且无鼠源 Tigit 表达。
Fig.2 TIGIT&PVR双人源化纯合子小鼠通过尾静脉注射刀豆蛋白（9mg/kg）刺激6h，取脾脏细胞进行流式验证，检测 Tigit&Pvr 双人源化小鼠脾脏中人源 PVR 的表达。结果显示：TIGIT&PVR人源化纯合子小鼠脾脏的细胞中人源 PVR 表达活跃，且无鼠源 Prv 表达。
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