hVISTA
品系全名
C57BL/6JSmo-Vsirtm1(hVSIR)/Smoc
目录号
NM-HU-00118
品系状态
活体
基因信息
基因名
Vsir
品系描述
验证数据
图1 FACS 检测人源化小鼠外周血T淋巴细胞中人源VISTA的表达。
结果显示： VISTA人源化纯合子小鼠外周血T淋巴细胞可以检测到人源VISTA的活跃表达。
图2 VISTA人源化小鼠MC38 荷瘤模型体内抗肿瘤药效验证。
VISTA人源化小鼠接种MC38结肠癌细胞系，随机分为对照组和实验组（n=6)，分别在第0，3，7，10，14，17天给药。结果显示抗人VISTA抗体可以显著抑制肿瘤生长（TGI: 抑瘤率 , p<0.01），表明VISTA人源化小鼠模型是研究小鼠抗人VISTA抗体体内药效的有力工具。（与WuXi Biologics合作完成）
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